2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-4-piperidinylacetamide trifluoroacetate

Base Information

Chemical Name:2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-4-piperidinylacetamide trifluoroacetate
CAS No.:1300746-18-2
Molecular Formula:C₂HF₃O₂*C₂₅H₂₇ClN₆O₂
Molecular Weight:593.005
Hs Code.:

Synonyms:2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-4-piperidinylacetamide trifluoroacetate

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Chemical Property of 2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-4-piperidinylacetamide trifluoroacetate

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Technology Process of 2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-4-piperidinylacetamide trifluoroacetate

There total 11 articles about 2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-4-piperidinylacetamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1300746-70-6
tert-butyl (S)-4-(2-(6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)acetamido)piperidine-1-carboxylate

: 76-05-1
trifluoroacetic acid

: 1300746-18-2
2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-4-piperidinylacetamide trifluoroacetate

Guidance literature:: In dichloromethane; at 25 ℃; for 2h; Inert atmosphere;

Reference yield:

: 873-77-8
(4-chlorphenyl)magnesium bromide

: 1300746-18-2
2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-4-piperidinylacetamide trifluoroacetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: toluene; diethyl ether / 1 h / 0 - 20 °C

1.2: 2 h / Reflux

2.1: chloroform / 1.5 h / 60 °C

3.1: triethylamine / dichloromethane / 24 h / Reflux

3.2: 2 h / 60 °C

4.1: tetraphosphorus decasulfide; sodium carbonate / 1,2-dichloro-ethane / 2 h / 70 °C

5.1: hydrazine hydrate / tetrahydrofuran / 4 h / 0 - 15 °C

5.2: 1 h / 20 °C

6.1: acetic acid / tetrahydrofuran / 48 h / 20 °C

7.1: sodium hydroxide / tetrahydrofuran / 5 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 50 °C / Inert atmosphere

9.1: dichloromethane / 2 h / 25 °C / Inert atmosphere

With tetraphosphorus decasulfide; sodium carbonate; hydrazine hydrate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 91713-54-1
[2-amino-5-(methyloxy)phenyl](4-chlorophenyl)methanone

: 1300746-18-2
2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-4-piperidinylacetamide trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: chloroform / 1.5 h / 60 °C

2.1: triethylamine / dichloromethane / 24 h / Reflux

2.2: 2 h / 60 °C

3.1: tetraphosphorus decasulfide; sodium carbonate / 1,2-dichloro-ethane / 2 h / 70 °C

4.1: hydrazine hydrate / tetrahydrofuran / 4 h / 0 - 15 °C

4.2: 1 h / 20 °C

5.1: acetic acid / tetrahydrofuran / 48 h / 20 °C

6.1: sodium hydroxide / tetrahydrofuran / 5 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 50 °C / Inert atmosphere

8.1: dichloromethane / 2 h / 25 °C / Inert atmosphere

With tetraphosphorus decasulfide; sodium carbonate; hydrazine hydrate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; dichloromethane; chloroform; 1,2-dichloro-ethane; N,N-dimethyl-formamide;