(2-Amino-5-methoxyphenyl)(4-chlorophenyl)methanone

Base Information

Chemical Name:(2-Amino-5-methoxyphenyl)(4-chlorophenyl)methanone
CAS No.:91713-54-1
Molecular Formula:C14H12ClNO2
Molecular Weight:261.708
Hs Code.:
DSSTox Substance ID:DTXSID601228059
Mol file:91713-54-1.mol

Synonyms:91713-54-1;(2-amino-5-methoxyphenyl)(4-chlorophenyl)methanone;[2-amino-5-(methyloxy)phenyl](4-chlorophenyl)methanone;Methanone, (2-amino-5-methoxyphenyl)(4-chlorophenyl)-;(2-amino-5-methoxyphenyl)-(4-chlorophenyl)methanone;SCHEMBL1820102;MIQUXYBYLZSOIJ-UHFFFAOYSA-N;DTXSID601228059;CS-M2015;AKOS013746248;CS-14539

Suppliers and Price of (2-Amino-5-methoxyphenyl)(4-chlorophenyl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
[2-Amino-5-(methyloxy)phenyl](4-chlorophenyl)methanone
500mg
$ 165.00

TRC
[2-Amino-5-(methyloxy)phenyl](4-chlorophenyl)methanone
5g
$ 1320.00

Chemenu
(2-Amino-5-methoxyphenyl)(4-chlorophenyl)methanone 95%
5g
$ 506.00

Alichem
(2-Amino-5-methoxyphenyl)(4-chlorophenyl)methanone
250mg
$ 388.96

Alichem
(2-Amino-5-methoxyphenyl)(4-chlorophenyl)methanone
1g
$ 980.70

AK Scientific
2-(4-Chlorobenzoyl)-4-methoxyaniline
250mg
$ 597.00

Total 6 raw suppliers

Chemical Property of (2-Amino-5-methoxyphenyl)(4-chlorophenyl)methanone

Chemical Property:

Melting Point:73-75.5 °C (ligroine)
Boiling Point:457.3±45.0 °C (760 mmHg)
PSA：52.32000
Density:1.271±0.06 g/cm3 (20 °C, 760 mmHg)
LogP:3.74300
XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:261.0556563
Heavy Atom Count:18
Complexity:290

Purity/Quality:

≥95% ^*data from raw suppliers

[2-Amino-5-(methyloxy)phenyl](4-chlorophenyl)methanone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=C(C=C1)N)C(=O)C2=CC=C(C=C2)Cl
Uses [2-Amino-5-(methyloxy)phenyl](4-chlorophenyl)methanone, can be used in the synthesis of inflammatory agents, such as acetylated histones mimic compound, and 2-amino-3-benzoylphenylacetic acid and analogs.

Technology Process of (2-Amino-5-methoxyphenyl)(4-chlorophenyl)methanone

There total 6 articles about (2-Amino-5-methoxyphenyl)(4-chlorophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 38527-50-3
2-methyl-6-(methoxy)-3,1-benzoxazin-4-one

: 873-77-8
(4-chlorphenyl)magnesium bromide

: 91713-54-1
[2-amino-5-(methyloxy)phenyl](4-chlorophenyl)methanone

Guidance literature:: 2-methyl-6-(methoxy)-3,1-benzoxazin-4-one; (4-chlorphenyl)magnesium bromide; In diethyl ether; toluene; at 0 - 20 ℃; for 1h;

With hydrogenchloride; water; In ethanol; for 2h; Reflux;

With sodium hydroxide; In ethyl acetate;

Reference yield: 69.0%

: 214971-09-2
2-amino-5,N-dimethoxy-N-methylbenzamide

: 106-39-8
bromochlorobenzene

: 91713-54-1
[2-amino-5-(methyloxy)phenyl](4-chlorophenyl)methanone

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;
DOI:10.1021/jm400652r

Reference yield:

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 91713-54-1
[2-amino-5-(methyloxy)phenyl](4-chlorophenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 3.5 h / Reflux

2.1: toluene; diethyl ether / 1 h / 0 - 20 °C

2.2: 2 h / Reflux

In diethyl ether; toluene;