N-{(1S)-1-[4-chloro-2-(1-{[(1R,2R)-2-(2,4-difluorophenyl)-4-oxocyclopentyl]carbonyl}-piperidin-4-yl)-5-methylphenyl]propyl}acetamide

Base Information

Chemical Name:N-{(1S)-1-[4-chloro-2-(1-{[(1R,2R)-2-(2,4-difluorophenyl)-4-oxocyclopentyl]carbonyl}-piperidin-4-yl)-5-methylphenyl]propyl}acetamide
CAS No.:1015485-89-8
Molecular Formula:C₂₉H₃₃ClF₂N₂O₃
Molecular Weight:531.042
Hs Code.:

Synonyms:N-{(1S)-1-[4-chloro-2-(1-{[(1R,2R)-2-(2,4-difluorophenyl)-4-oxocyclopentyl]carbonyl}-piperidin-4-yl)-5-methylphenyl]propyl}acetamide

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Chemical Property of N-{(1S)-1-[4-chloro-2-(1-{[(1R,2R)-2-(2,4-difluorophenyl)-4-oxocyclopentyl]carbonyl}-piperidin-4-yl)-5-methylphenyl]propyl}acetamide

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Technology Process of N-{(1S)-1-[4-chloro-2-(1-{[(1R,2R)-2-(2,4-difluorophenyl)-4-oxocyclopentyl]carbonyl}-piperidin-4-yl)-5-methylphenyl]propyl}acetamide

There total 1 articles about N-{(1S)-1-[4-chloro-2-(1-{[(1R,2R)-2-(2,4-difluorophenyl)-4-oxocyclopentyl]carbonyl}-piperidin-4-yl)-5-methylphenyl]propyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1015485-46-7
N-{(1S)-1-[4-chloro-2-(1-{[(1R,2R)-2-(2,4-difluorophenyl)-4-methylene-cyclopentyl]carbonyl}-piperidin-4-yl)-5-methylphenyl]propyl}acetamide

: 1015485-89-8
N-{(1S)-1-[4-chloro-2-(1-{[(1R,2R)-2-(2,4-difluorophenyl)-4-oxocyclopentyl]carbonyl}-piperidin-4-yl)-5-methylphenyl]propyl}acetamide

Guidance literature:: With sodium periodate; osmium(VIII) oxide; In tetrahydrofuran; water; tert-butyl alcohol; at 20 ℃; for 1.5h;

Reference yield:

: 1015485-89-8
N-{(1S)-1-[4-chloro-2-(1-{[(1R,2R)-2-(2,4-difluorophenyl)-4-oxocyclopentyl]carbonyl}-piperidin-4-yl)-5-methylphenyl]propyl}acetamide

: 76-05-1
trifluoroacetic acid

: methyl (4R)-1-[(3R,4R)-3-[(4-{2-[(1S)-1-(acetylamino)propyl]-5-chloro-4-methylphenyl}piperidin-1-yl)carbonyl]-4-(2,4-difluorophenyl)cyclopentyl]-4-hydroxy-D-prolinate trifluoroacetate

Guidance literature:: N-{(1S)-1-[4-chloro-2-(1-{[(1R,2R)-2-(2,4-difluorophenyl)-4-oxocyclopentyl]carbonyl}-piperidin-4-yl)-5-methylphenyl]propyl}acetamide; (2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid methyl ester; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h; Molecular sieve;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;

trifluoroacetic acid;

Reference yield:

: 1015485-89-8
N-{(1S)-1-[4-chloro-2-(1-{[(1R,2R)-2-(2,4-difluorophenyl)-4-oxocyclopentyl]carbonyl}-piperidin-4-yl)-5-methylphenyl]propyl}acetamide

: 136725-53-6,169750-17-8,136725-55-8
(S)-3-fluoropyrrolidine hydrochloride

: N-((1S)-1-{4-chloro-2-[1-({(1R,2R,4S)-2-(2,4-difluorophenyl)-4-[(3S)-3-fluoropyrrolidin-1-yl]cyclopentyl}carbonyl)piperidin-4-yl]-5-methylphenyl}propyl)acetamide

: N-((1S)-1-{4-chloro-2-[1-({(1R,2R,4R)-2-(2,4-difluorophenyl)-4-[(3S)-3-fluoropyrrolidin-1-yl]cyclopentyl}carbonyl)piperidin-4-yl]-5-methylphenyl}propyl)acetamide

Guidance literature:: N-{(1S)-1-[4-chloro-2-(1-{[(1R,2R)-2-(2,4-difluorophenyl)-4-oxocyclopentyl]carbonyl}-piperidin-4-yl)-5-methylphenyl]propyl}acetamide; (S)-3-fluoropyrrolidine hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h; Molecular sieve;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;