N-{(1S)-1-[4-chloro-2-(1-{[(1R,2R)-2-(2,4-difluorophenyl)-4-methylene-cyclopentyl]carbonyl}-piperidin-4-yl)-5-methylphenyl]propyl}acetamide

Base Information

• Chemical Name: N-{(1S)-1-[4-chloro-2-(1-{[(1R,2R)-2-(2,4-difluorophenyl)-4-methylene-cyclopentyl]carbonyl}-piperidin-4-yl)-5-methylphenyl]propyl}acetamide
• CAS No.: 1015485-46-7
• Molecular Formula: C₃₀H₃₅ClF₂N₂O₂
• Molecular Weight: 529.07

Synonyms:N-{(1S)-1-[4-chloro-2-(1-{[(1R,2R)-2-(2,4-difluorophenyl)-4-methylene-cyclopentyl]carbonyl}-piperidin-4-yl)-5-methylphenyl]propyl}acetamide

Chemical Property of N-{(1S)-1-[4-chloro-2-(1-{[(1R,2R)-2-(2,4-difluorophenyl)-4-methylene-cyclopentyl]carbonyl}-piperidin-4-yl)-5-methylphenyl]propyl}acetamide

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Technology Process of N-{(1S)-1-[4-chloro-2-(1-{[(1R,2R)-2-(2,4-difluorophenyl)-4-methylene-cyclopentyl]carbonyl}-piperidin-4-yl)-5-methylphenyl]propyl}acetamide

There total 1 articles about N-{(1S)-1-[4-chloro-2-(1-{[(1R,2R)-2-(2,4-difluorophenyl)-4-methylene-cyclopentyl]carbonyl}-piperidin-4-yl)-5-methylphenyl]propyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H25ClN2O (1015841-52-7) + (1R,2R)-2-(2,4-difluorophenyl)-4-methylenecyclopentanecarboxylic acid (934196-06-2) → N-{(1S)-1-[4-chloro-2-(1-{[(1R,2R)-2-(2,4-difluorophenyl)-4-methylene-cyclopentyl]carbonyl}-piperidin-4-yl)-5-methylphenyl]propyl}acetamide (1015485-46-7)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃;

Reference yield:

N-{(1S)-1-[4-chloro-2-(1-{[(1R,2R)-2-(2,4-difluorophenyl)-4-methylene-cyclopentyl]carbonyl}-piperidin-4-yl)-5-methylphenyl]propyl}acetamide (1015485-46-7) → N-{(1S)-1-[4-chloro-2-(1-{[(1R,2R)-2-(2,4-difluorophenyl)-4-oxocyclopentyl]carbonyl}-piperidin-4-yl)-5-methylphenyl]propyl}acetamide (1015485-89-8)

Guidance literature:

With sodium periodate; osmium(VIII) oxide; In tetrahydrofuran; water; tert-butyl alcohol; at 20 ℃; for 1.5h;

upstream raw materials:

C₁₇H₂₅ClN₂O

(1R,2R)-2-(2,4-difluorophenyl)-4-methylenecyclopentanecarboxylic acid

Downstream raw materials:

N-{(1S)-1-[4-chloro-2-(1-{[(1R,2R)-2-(2,4-difluorophenyl)-4-oxocyclopentyl]carbonyl}-piperidin-4-yl)-5-methylphenyl]propyl}acetamide

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