(3aR,4'S,5S,6aR)-3'-benzyl-5-[(benzyloxy)methyl]-2,2-dimethyldihydro-3aH-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

Base Information

Chemical Name:(3aR,4'S,5S,6aR)-3'-benzyl-5-[(benzyloxy)methyl]-2,2-dimethyldihydro-3aH-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one
CAS No.:1421940-21-7
Molecular Formula:C₂₄H₂₇NO₆
Molecular Weight:425.481
Hs Code.:

Synonyms:(3aR,4'S,5S,6aR)-3'-benzyl-5-[(benzyloxy)methyl]-2,2-dimethyldihydro-3aH-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

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Chemical Property of (3aR,4'S,5S,6aR)-3'-benzyl-5-[(benzyloxy)methyl]-2,2-dimethyldihydro-3aH-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

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Technology Process of (3aR,4'S,5S,6aR)-3'-benzyl-5-[(benzyloxy)methyl]-2,2-dimethyldihydro-3aH-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

There total 1 articles about (3aR,4'S,5S,6aR)-3'-benzyl-5-[(benzyloxy)methyl]-2,2-dimethyldihydro-3aH-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1382153-80-1
(3aR,4'S,5S,6aR)-3'-benzyl-5-(hydroxymethyl)-2,2-dimethyldihydro-3aH-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

: 100-39-0
benzyl bromide

: 1421940-21-7
(3aR,4'S,5S,6aR)-3'-benzyl-5-[(benzyloxy)methyl]-2,2-dimethyldihydro-3aH-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

Guidance literature:: (3aR,4'S,5S,6aR)-3'-benzyl-5-(hydroxymethyl)-2,2-dimethyldihydro-3aH-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one; With tetra-(n-butyl)ammonium iodide; sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.25h; Inert atmosphere;

benzyl bromide; With tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 1.5h; Inert atmosphere;
DOI:10.1016/j.tetasy.2012.12.003

Reference yield: 81.0%

: 1421940-21-7
(3aR,4'S,5S,6aR)-3'-benzyl-5-[(benzyloxy)methyl]-2,2-dimethyldihydro-3aH-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

: 1430738-72-9
C₂₁H₂₃NO₆

Guidance literature:: With trifluoroacetic acid; In water; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.tetasy.2012.12.003

Reference yield:

: 1421940-21-7
(3aR,4'S,5S,6aR)-3'-benzyl-5-[(benzyloxy)methyl]-2,2-dimethyldihydro-3aH-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

: 1421940-24-0
ethyl (4S,2E)-4-{(4R)-3-benzyl-4-[(1S)-2-(benzyloxy)-1-hydroxyethyl]-2-oxooxazolidin-4-yl}-4-hydroxybut-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / water / 3 h / 20 °C / Inert atmosphere

2: benzoic acid / water / 26.5 h / 20 °C / Inert atmosphere

With benzoic acid; trifluoroacetic acid; In water;
DOI:10.1016/j.tetasy.2012.12.003