ethyl 1-[1-(4-chlorophenyl)-2-cyanoallyl]-2-oxocyclopentanecarboxylate

Base Information

• Chemical Name: ethyl 1-[1-(4-chlorophenyl)-2-cyanoallyl]-2-oxocyclopentanecarboxylate
• CAS No.: 1020667-35-9
• Molecular Formula: C₁₈H₁₈ClNO₃
• Molecular Weight: 331.799
• Mol file: 1020667-35-9.mol

Synonyms:ethyl 1-[1-(4-chlorophenyl)-2-cyanoallyl]-2-oxocyclopentanecarboxylate

Chemical Property of ethyl 1-[1-(4-chlorophenyl)-2-cyanoallyl]-2-oxocyclopentanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of ethyl 1-[1-(4-chlorophenyl)-2-cyanoallyl]-2-oxocyclopentanecarboxylate

There total 1 articles about ethyl 1-[1-(4-chlorophenyl)-2-cyanoallyl]-2-oxocyclopentanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-ethoxycarbonyl-1-cyclopentanone (611-10-9) + Acetic acid 1-(4-chloro-phenyl)-2-cyano-allyl ester (164208-54-2) → ethyl 1-[1-(4-chlorophenyl)-2-cyanoallyl]-2-oxocyclopentanecarboxylate (1020667-35-9)

Guidance literature:

Acetic acid 1-(4-chloro-phenyl)-2-cyano-allyl ester; With 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; water; at 20 ℃; for 0.25h;

2-ethoxycarbonyl-1-cyclopentanone; In tetrahydrofuran; water; at 20 ℃; for 2h; Further stages.;

DOI:10.1016/j.tet.2008.01.074

Reference yield:

ethyl 1-[1-(4-chlorophenyl)-2-cyanoallyl]-2-oxocyclopentanecarboxylate (1020667-35-9) → cis-ethyl 4-(4-chlorophenyl)-3-methylene-2-oxo-1,2,3,4,5,6-hexahydro-4aH-cyclopenta[b]pyridine-4a-carboxylate + trans-ethyl 4-(4-chlorophenyl)-3-methylene-2-oxo-1,2,3,4,5,6-hexahydro-4aH-cyclopenta[b]pyridine-4a-carboxylate

Guidance literature:

With sulfuric acid; trifluoroacetic acid; at 20 ℃; for 0.116667h;

DOI:10.1016/j.tet.2008.01.074

upstream raw materials:

2-ethoxycarbonyl-1-cyclopentanone

Acetic acid 1-(4-chloro-phenyl)-2-cyano-allyl ester