3-(5-phenyl-4-(trifluoromethyl)isoxazole-3-yl)-8-bromo-2,3-dihydrobenzo[b]oxepino-[4,5-d]isoxazole

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Chemical Name:3-(5-phenyl-4-(trifluoromethyl)isoxazole-3-yl)-8-bromo-2,3-dihydrobenzo[b]oxepino-[4,5-d]isoxazole
CAS No.:1307813-28-0
Molecular Formula:C₂₁H₁₂BrF₃N₂O₃
Molecular Weight:477.237
Hs Code.:

Synonyms:3-(5-phenyl-4-(trifluoromethyl)isoxazole-3-yl)-8-bromo-2,3-dihydrobenzo[b]oxepino-[4,5-d]isoxazole

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Chemical Property of 3-(5-phenyl-4-(trifluoromethyl)isoxazole-3-yl)-8-bromo-2,3-dihydrobenzo[b]oxepino-[4,5-d]isoxazole

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Technology Process of 3-(5-phenyl-4-(trifluoromethyl)isoxazole-3-yl)-8-bromo-2,3-dihydrobenzo[b]oxepino-[4,5-d]isoxazole

There total 13 articles about 3-(5-phenyl-4-(trifluoromethyl)isoxazole-3-yl)-8-bromo-2,3-dihydrobenzo[b]oxepino-[4,5-d]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1307813-27-9
(E)-4-(8-bromo-2,3-dihydrobenzo[b]oxepin-5-yl)morpholine

: 1307812-25-4
N-hydroxy-5-phenyl-4-(trifluoromethyl)isoxazole-3-carbimidoyl chloride

: 1307813-28-0
3-(5-phenyl-4-(trifluoromethyl)isoxazole-3-yl)-8-bromo-2,3-dihydrobenzo[b]oxepino-[4,5-d]isoxazole

Guidance literature:: (E)-4-(8-bromo-2,3-dihydrobenzo[b]oxepin-5-yl)morpholine; N-hydroxy-5-phenyl-4-(trifluoromethyl)isoxazole-3-carbimidoyl chloride; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 0.533333h;

With trifluoroacetic acid; In 1,2-dichloro-ethane; at 80 ℃; for 1h;

Reference yield:

: 7063-99-2
ethyl 5-phenylisoxazole-3-carboxylate

: 1307813-28-0
3-(5-phenyl-4-(trifluoromethyl)isoxazole-3-yl)-8-bromo-2,3-dihydrobenzo[b]oxepino-[4,5-d]isoxazole

Guidance literature:: Multi-step reaction with 8 steps

1.1: trifluoroacetic acid; N-iodo-succinimide / 3.5 h / 20 °C

2.1: N,N,N,N,N,N-hexamethylphosphoric triamide / copper(l) iodide / N,N-dimethyl-formamide / 20 - 80 °C

3.1: lithium hydroxide monohydrate / water; methanol / 0.5 h / 20 °C

3.2: pH 1

4.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / 0 °C

4.2: 1 h / -78 °C

5.1: Dess-Martin periodane / dichloromethane / 1.17 h / 0 - 20 °C

6.1: hydroxylamine hydrochloride; sodium acetate / methanol / 0.75 h / Reflux

7.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 20 °C

8.1: triethylamine / dichloromethane / 0.53 h / 0 - 20 °C

8.2: 1 h / 80 °C

With 4-methyl-morpholine; N,N,N,N,N,N-hexamethylphosphoric triamide; N-chloro-succinimide; N-iodo-succinimide; lithium hydroxide monohydrate; hydroxylamine hydrochloride; sodium acetate; Dess-Martin periodane; triethylamine; trifluoroacetic acid; isobutyl chloroformate; copper(l) iodide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 536-74-3
phenylacetylene

: 1307813-28-0
3-(5-phenyl-4-(trifluoromethyl)isoxazole-3-yl)-8-bromo-2,3-dihydrobenzo[b]oxepino-[4,5-d]isoxazole

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine / diethyl ether / 3 h / 20 °C

2.1: trifluoroacetic acid; N-iodo-succinimide / 3.5 h / 20 °C

3.1: N,N,N,N,N,N-hexamethylphosphoric triamide / copper(l) iodide / N,N-dimethyl-formamide / 20 - 80 °C

4.1: lithium hydroxide monohydrate / water; methanol / 0.5 h / 20 °C

4.2: pH 1

5.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / 0 °C

5.2: 1 h / -78 °C

6.1: Dess-Martin periodane / dichloromethane / 1.17 h / 0 - 20 °C

7.1: hydroxylamine hydrochloride; sodium acetate / methanol / 0.75 h / Reflux

8.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 20 °C

9.1: triethylamine / dichloromethane / 0.53 h / 0 - 20 °C

9.2: 1 h / 80 °C

With 4-methyl-morpholine; N,N,N,N,N,N-hexamethylphosphoric triamide; N-chloro-succinimide; N-iodo-succinimide; lithium hydroxide monohydrate; hydroxylamine hydrochloride; sodium acetate; Dess-Martin periodane; triethylamine; trifluoroacetic acid; isobutyl chloroformate; copper(l) iodide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;