N-[2-hydroxy-5-(9-phenyl-9H-xanthen-9-yloxy)-cyclopentyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide

Base Information

Chemical Name:N-[2-hydroxy-5-(9-phenyl-9H-xanthen-9-yloxy)-cyclopentyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide
CAS No.:673458-65-6
Molecular Formula:C₃₁H₂₉N₃O₆
Molecular Weight:539.588
Hs Code.:

<i>N</i>-[2-hydroxy-5-(9-phenyl-9<i>H</i>-xanthen-9-yloxy)-cyclopentyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-acetamide

Synonyms:N-[2-hydroxy-5-(9-phenyl-9H-xanthen-9-yloxy)-cyclopentyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide

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Chemical Property of N-[2-hydroxy-5-(9-phenyl-9H-xanthen-9-yloxy)-cyclopentyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide

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Technology Process of N-[2-hydroxy-5-(9-phenyl-9H-xanthen-9-yloxy)-cyclopentyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide

There total 12 articles about N-[2-hydroxy-5-(9-phenyl-9H-xanthen-9-yloxy)-cyclopentyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 673458-63-4
N-[2-(tert-butyl(dimethyl)silyloxy)-5-(9-phenylxanthen-9-yloxy)cyclopentyl]-2-(thymin-1-yl)acetamide

: 673458-65-6
N-[2-hydroxy-5-(9-phenyl-9H-xanthen-9-yloxy)-cyclopentyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;
DOI:10.1081/NCN-120022837

Reference yield:

: 34310-95-7
trans-6-oxabicyclo<3.1.0>hexan-2-ol

: 673458-65-6
N-[2-hydroxy-5-(9-phenyl-9H-xanthen-9-yloxy)-cyclopentyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: 79 percent / toluene / 90 °C

2.1: 76 percent / NaH / dimethylformamide / 20 °C

3.1: 97 percent / 4-(dimethylamino)pyridine; pyridine / 20 °C

4.1: 31 percent / porcine liver esterase / aq. phosphate buffer / 30 °C / pH 7

5.1: 82 percent / KOH / ethanol / 80 °C

6.1: 98 percent / hydrogen / Pd/C / methanol / 20 °C

7.1: 65 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide / dimethylformamide / 20 °C

8.1: pyridine / dimethylsulfoxide / 20 °C

8.2: 33 percent / imidazole / dimethylformamide / 20 °C

9.1: 92 percent / tetrabutylammonium fluoride / tetrahydrofuran / 20 °C

With pyridine; porcine liver esterase; dmap; potassium hydroxide; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; phosphate buffer; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1081/NCN-120022837

Reference yield:

: (1α,2β,5α)-2-(tert-butyldimethylsilyloxy)-6-oxabicyclo<3.1.0>hexane

: 673458-65-6
N-[2-hydroxy-5-(9-phenyl-9H-xanthen-9-yloxy)-cyclopentyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: 93 percent / tetrabutylammonium fluoride / tetrahydrofuran / 20 °C

2.1: 79 percent / toluene / 90 °C

3.1: 76 percent / NaH / dimethylformamide / 20 °C

4.1: 97 percent / 4-(dimethylamino)pyridine; pyridine / 20 °C

5.1: 31 percent / porcine liver esterase / aq. phosphate buffer / 30 °C / pH 7

6.1: 82 percent / KOH / ethanol / 80 °C

7.1: 98 percent / hydrogen / Pd/C / methanol / 20 °C

8.1: 65 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide / dimethylformamide / 20 °C

9.1: pyridine / dimethylsulfoxide / 20 °C

9.2: 33 percent / imidazole / dimethylformamide / 20 °C

10.1: 92 percent / tetrabutylammonium fluoride / tetrahydrofuran / 20 °C

With pyridine; porcine liver esterase; dmap; potassium hydroxide; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; phosphate buffer; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1081/NCN-120022837