N-[2-(tert-butyl(dimethyl)silyloxy)-5-(9-phenylxanthen-9-yloxy)cyclopentyl]-2-(thymin-1-yl)acetamide

Base Information

Chemical Name:N-[2-(tert-butyl(dimethyl)silyloxy)-5-(9-phenylxanthen-9-yloxy)cyclopentyl]-2-(thymin-1-yl)acetamide
CAS No.:673458-63-4
Molecular Formula:C₃₇H₄₃N₃O₆Si
Molecular Weight:653.85
Hs Code.:

Synonyms:N-[2-(tert-butyl(dimethyl)silyloxy)-5-(9-phenylxanthen-9-yloxy)cyclopentyl]-2-(thymin-1-yl)acetamide

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Chemical Property of N-[2-(tert-butyl(dimethyl)silyloxy)-5-(9-phenylxanthen-9-yloxy)cyclopentyl]-2-(thymin-1-yl)acetamide

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Technology Process of N-[2-(tert-butyl(dimethyl)silyloxy)-5-(9-phenylxanthen-9-yloxy)cyclopentyl]-2-(thymin-1-yl)acetamide

There total 14 articles about N-[2-(tert-butyl(dimethyl)silyloxy)-5-(9-phenylxanthen-9-yloxy)cyclopentyl]-2-(thymin-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 42506-03-6
pixyl chloride

: 18162-48-6
tert-butyldimethylsilyl chloride

: 611183-01-8
N-(2,5-dihydroxycyclopentyl)-2-(thymin-1-yl)acetamide

: 673458-63-4
N-[2-(tert-butyl(dimethyl)silyloxy)-5-(9-phenylxanthen-9-yloxy)cyclopentyl]-2-(thymin-1-yl)acetamide

Guidance literature:: pixyl chloride; N-(2,5-dihydroxycyclopentyl)-2-(thymin-1-yl)acetamide; With pyridine; In dimethyl sulfoxide; at 20 ℃;

tert-butyldimethylsilyl chloride; With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1081/NCN-120022837

Reference yield:

: 68845-73-8
tert-butyl(cyclopent-2-en-1-yloxy)dimethylsilane

: 673458-63-4
N-[2-(tert-butyl(dimethyl)silyloxy)-5-(9-phenylxanthen-9-yloxy)cyclopentyl]-2-(thymin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: 42 percent / m-chloroperoxybenzoic acid / CH₂Cl₂ / 20 °C

2.1: 93 percent / tetrabutylammonium fluoride / tetrahydrofuran / 20 °C

3.1: 79 percent / toluene / 90 °C

4.1: 76 percent / NaH / dimethylformamide / 20 °C

5.1: 97 percent / 4-(dimethylamino)pyridine; pyridine / 20 °C

6.1: 31 percent / porcine liver esterase / aq. phosphate buffer / 30 °C / pH 7

7.1: 82 percent / KOH / ethanol / 80 °C

8.1: 98 percent / hydrogen / Pd/C / methanol / 20 °C

9.1: 65 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide / dimethylformamide / 20 °C

10.1: pyridine / dimethylsulfoxide / 20 °C

10.2: 33 percent / imidazole / dimethylformamide / 20 °C

With pyridine; porcine liver esterase; dmap; potassium hydroxide; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; phosphate buffer; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1081/NCN-120022837

Reference yield:

: 34310-95-7
trans-6-oxabicyclo<3.1.0>hexan-2-ol

: 673458-63-4
N-[2-(tert-butyl(dimethyl)silyloxy)-5-(9-phenylxanthen-9-yloxy)cyclopentyl]-2-(thymin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: 79 percent / toluene / 90 °C

2.1: 76 percent / NaH / dimethylformamide / 20 °C

3.1: 97 percent / 4-(dimethylamino)pyridine; pyridine / 20 °C

4.1: 31 percent / porcine liver esterase / aq. phosphate buffer / 30 °C / pH 7

5.1: 82 percent / KOH / ethanol / 80 °C

6.1: 98 percent / hydrogen / Pd/C / methanol / 20 °C

7.1: 65 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide / dimethylformamide / 20 °C

8.1: pyridine / dimethylsulfoxide / 20 °C

8.2: 33 percent / imidazole / dimethylformamide / 20 °C

With pyridine; porcine liver esterase; dmap; potassium hydroxide; hydrogen; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In methanol; phosphate buffer; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1081/NCN-120022837