(1R,2S)-2-Benzyloxymethyl-cyclopropane-1,1-dicarboxylic acid ethyl ester

Base Information

Chemical Name:(1R,2S)-2-Benzyloxymethyl-cyclopropane-1,1-dicarboxylic acid ethyl ester
CAS No.:185462-74-2
Molecular Formula:C₁₅H₁₈O₅
Molecular Weight:278.305
Hs Code.:

Synonyms:(1R,2S)-2-Benzyloxymethyl-cyclopropane-1,1-dicarboxylic acid ethyl ester

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Chemical Property of (1R,2S)-2-Benzyloxymethyl-cyclopropane-1,1-dicarboxylic acid ethyl ester

Chemical Property:

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Technology Process of (1R,2S)-2-Benzyloxymethyl-cyclopropane-1,1-dicarboxylic acid ethyl ester

There total 5 articles about (1R,2S)-2-Benzyloxymethyl-cyclopropane-1,1-dicarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 185462-73-1
(S)-2-Benzyloxymethyl-cyclopropane-1,1-dicarboxylic acid diethyl ester

: 185462-74-2
(1R,2S)-2-Benzyloxymethyl-cyclopropane-1,1-dicarboxylic acid ethyl ester

Guidance literature:: With sodium carbonate; In ethanol; at 60 ℃; for 20h;
DOI:10.1055/s-1996-4425

Reference yield:

: 17325-85-8
(2S)-3-(benzyloxy)propane-1,2-diol

: 185462-74-2
(1R,2S)-2-Benzyloxymethyl-cyclopropane-1,1-dicarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) thionyl chloride, 2.) RuCl₃*3H₂O, NaIO₄ / 1.) CCl₄, reflux, 30 min, 2.) CCl₄, MeCN, H₂O, 25 deg C, 60 min

2: 1.) NaH / 1.) DMF, 25 deg C, 2.) DMF, 85 deg C, 35 h

3: aq. Na₂CO₃ / ethanol / 20 h / 60 °C

With ruthenium trichloride; sodium periodate; thionyl chloride; sodium hydride; sodium carbonate; In ethanol;
DOI:10.1055/s-1996-4425

Reference yield:

: 185838-02-2
(4R)-4-(phenylmethoxymethyl)-1,3,2-dioxathiolane 2,2-dioxide

: 185462-74-2
(1R,2S)-2-Benzyloxymethyl-cyclopropane-1,1-dicarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, 25 deg C, 2.) DMF, 85 deg C, 35 h

2: aq. Na₂CO₃ / ethanol / 20 h / 60 °C

With sodium hydride; sodium carbonate; In ethanol;
DOI:10.1055/s-1996-4425