(1S,2S)-N-(2,4-difluorobenzyl)-9'-hydroxy-2-(hydroxymethyl)-2'-isopropyl-1',8'-dioxo-1',2',3',8'-tetrahydrospiro[cyclopropane-1,4'-pyrido[1,2-a]pyrazine]-7'-carboxamide hydrochloride

Base Information

Chemical Name:(1S,2S)-N-(2,4-difluorobenzyl)-9'-hydroxy-2-(hydroxymethyl)-2'-isopropyl-1',8'-dioxo-1',2',3',8'-tetrahydrospiro[cyclopropane-1,4'-pyrido[1,2-a]pyrazine]-7'-carboxamide hydrochloride
CAS No.:1616599-52-0
Molecular Formula:C₂₂H₂₃F₂N₃O₅*ClH
Molecular Weight:483.899
Hs Code.:

(1S,2S)-N-(2,4-difluorobenzyl)-9'-hydroxy-2-(hydroxymethyl)-2'-isopropyl-1',8'-dioxo-1',2',3',8'-tetrahydrospiro[cyclopropane-1,4'-pyrido[1,2-a]pyrazine]-7'-carboxamide hydrochloride

Synonyms:(1S,2S)-N-(2,4-difluorobenzyl)-9'-hydroxy-2-(hydroxymethyl)-2'-isopropyl-1',8'-dioxo-1',2',3',8'-tetrahydrospiro[cyclopropane-1,4'-pyrido[1,2-a]pyrazine]-7'-carboxamide hydrochloride

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Chemical Property of (1S,2S)-N-(2,4-difluorobenzyl)-9'-hydroxy-2-(hydroxymethyl)-2'-isopropyl-1',8'-dioxo-1',2',3',8'-tetrahydrospiro[cyclopropane-1,4'-pyrido[1,2-a]pyrazine]-7'-carboxamide hydrochloride

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Technology Process of (1S,2S)-N-(2,4-difluorobenzyl)-9'-hydroxy-2-(hydroxymethyl)-2'-isopropyl-1',8'-dioxo-1',2',3',8'-tetrahydrospiro[cyclopropane-1,4'-pyrido[1,2-a]pyrazine]-7'-carboxamide hydrochloride

There total 8 articles about (1S,2S)-N-(2,4-difluorobenzyl)-9'-hydroxy-2-(hydroxymethyl)-2'-isopropyl-1',8'-dioxo-1',2',3',8'-tetrahydrospiro[cyclopropane-1,4'-pyrido[1,2-a]pyrazine]-7'-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₂₉F₂N₃O₅

: 1616599-52-0
(1S,2S)-N-(2,4-difluorobenzyl)-9'-hydroxy-2-(hydroxymethyl)-2'-isopropyl-1',8'-dioxo-1',2',3',8'-tetrahydrospiro[cyclopropane-1,4'-pyrido[1,2-a]pyrazine]-7'-carboxamide hydrochloride

Guidance literature:: C₂₉H₂₉F₂N₃O₅; With trifluoroacetic acid; for 0.5h;

With hydrogenchloride; In methanol; ethyl acetate;

Reference yield:

: 185462-73-1
(S)-2-Benzyloxymethyl-cyclopropane-1,1-dicarboxylic acid diethyl ester

: 1616599-52-0
(1S,2S)-N-(2,4-difluorobenzyl)-9'-hydroxy-2-(hydroxymethyl)-2'-isopropyl-1',8'-dioxo-1',2',3',8'-tetrahydrospiro[cyclopropane-1,4'-pyrido[1,2-a]pyrazine]-7'-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium carbonate; water / ethanol / 9 h / 60 °C

2.1: triethylamine; diphenyl phosphoryl azide / tert-butyl alcohol / Reflux; Heating

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C / Cooling with ice

3.2: 0.5 h / 20 °C

4.1: chloroform; dimethyl sulfoxide / 0.28 h / -60 - -50 °C

4.2: 0.08 h / -60 - -50 °C

5.1: acetic acid; sodium tris(acetoxy)borohydride / chloroform

6.1: acetic acid; hydrogen / ethanol / 3 h / 20 °C

7.1: hydrogenchloride / 1,4-dioxane / 1 h

8.1: triethylamine / ethanol; tetrahydrofuran / 1 h / 20 °C

8.2: 1 h

8.3: 1 h / 100 °C

9.1: trifluoroacetic acid / 0.5 h

With hydrogenchloride; lithium aluminium tetrahydride; diphenyl phosphoryl azide; water; hydrogen; sodium tris(acetoxy)borohydride; sodium carbonate; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; chloroform; dimethyl sulfoxide; tert-butyl alcohol;

Reference yield:

: 185462-74-2
(1R,2S)-2-Benzyloxymethyl-cyclopropane-1,1-dicarboxylic acid ethyl ester

: 1616599-52-0
(1S,2S)-N-(2,4-difluorobenzyl)-9'-hydroxy-2-(hydroxymethyl)-2'-isopropyl-1',8'-dioxo-1',2',3',8'-tetrahydrospiro[cyclopropane-1,4'-pyrido[1,2-a]pyrazine]-7'-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine; diphenyl phosphoryl azide / tert-butyl alcohol / Reflux; Heating

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C / Cooling with ice

2.2: 0.5 h / 20 °C

3.1: chloroform; dimethyl sulfoxide / 0.28 h / -60 - -50 °C

3.2: 0.08 h / -60 - -50 °C

4.1: acetic acid; sodium tris(acetoxy)borohydride / chloroform

5.1: acetic acid; hydrogen / ethanol / 3 h / 20 °C

6.1: hydrogenchloride / 1,4-dioxane / 1 h

7.1: triethylamine / ethanol; tetrahydrofuran / 1 h / 20 °C

7.2: 1 h

7.3: 1 h / 100 °C

8.1: trifluoroacetic acid / 0.5 h

With hydrogenchloride; lithium aluminium tetrahydride; diphenyl phosphoryl azide; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; chloroform; dimethyl sulfoxide; tert-butyl alcohol;