(Z)-1-methylsulfonyloxy-9-(4-methylphenylsulfonamido)non-4-ene-2,6-diyne

Base Information

Chemical Name:(Z)-1-methylsulfonyloxy-9-(4-methylphenylsulfonamido)non-4-ene-2,6-diyne
CAS No.:195608-41-4
Molecular Formula:C₁₇H₁₉NO₅S₂
Molecular Weight:381.474
Hs Code.:

Synonyms:(Z)-1-methylsulfonyloxy-9-(4-methylphenylsulfonamido)non-4-ene-2,6-diyne

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-1-methylsulfonyloxy-9-(4-methylphenylsulfonamido)non-4-ene-2,6-diyne

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Technology Process of (Z)-1-methylsulfonyloxy-9-(4-methylphenylsulfonamido)non-4-ene-2,6-diyne

There total 7 articles about (Z)-1-methylsulfonyloxy-9-(4-methylphenylsulfonamido)non-4-ene-2,6-diyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 124-63-0
methanesulfonyl chloride

: 292152-95-5
9-(4-methylphenylsulfonamido)non-4-ene-2,6-di-diyne-1-ol

: 195608-41-4
(Z)-1-methylsulfonyloxy-9-(4-methylphenylsulfonamido)non-4-ene-2,6-diyne

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 0.25h;

Reference yield:

: 114534-21-3
(Z)-6-chlorohex-5-en-3-yn-1-ol

: 195608-41-4
(Z)-1-methylsulfonyloxy-9-(4-methylphenylsulfonamido)non-4-ene-2,6-diyne

Guidance literature:: Multi-step reaction with 7 steps

1: 85 percent / Et₃N / CH₂Cl₂ / 0.25 h / 20 °C

2: 80 percent / NaN₃ / dimethylformamide / 4 h / 20 °C

3: aq. PPh₃ / tetrahydrofuran / 20 h / 20 °C

4: 200 mg / DMAP / CH₂Cl₂ / 3 h

5: 70 percent / n-BuNH₂; CuI / Pd(PPh₃)4 / benzene / 3 h / 40 °C

6: 90 percent / CsF / acetonitrile / 4 h / 20 °C

7: 85 percent / Et₃N / CH₂Cl₂ / 0.25 h / 20 °C

With dmap; copper(l) iodide; sodium azide; N-butylamine; triethylamine; triphenylphosphine; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; benzene; 1: Substitution / 2: Substitution / 3: Reduction / 4: Tosylation / 5: Alkylation / 6: Substitution / 7: Substitution;
DOI:10.1039/b000963f

Reference yield:

: 195608-38-9
(Z)-1-amino-6-chlorohex-5-en-3-yne

: 195608-41-4
(Z)-1-methylsulfonyloxy-9-(4-methylphenylsulfonamido)non-4-ene-2,6-diyne

Guidance literature:: Multi-step reaction with 4 steps

1: 200 mg / DMAP / CH₂Cl₂ / 3 h

2: 70 percent / n-BuNH₂; CuI / Pd(PPh₃)4 / benzene / 3 h / 40 °C

3: 90 percent / CsF / acetonitrile / 4 h / 20 °C

4: 85 percent / Et₃N / CH₂Cl₂ / 0.25 h / 20 °C

With dmap; copper(l) iodide; N-butylamine; triethylamine; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; acetonitrile; benzene; 1: Tosylation / 2: Alkylation / 3: Substitution / 4: Substitution;
DOI:10.1039/b000963f