6-butyl-3-(4-ethoxyphenyl)-5-(4-hydroxy-3,5-dipropylbenzyl)-2-methylpyrimidin-4(3H)-one

Base Information

Chemical Name:6-butyl-3-(4-ethoxyphenyl)-5-(4-hydroxy-3,5-dipropylbenzyl)-2-methylpyrimidin-4(3H)-one
CAS No.:1256780-12-7
Molecular Formula:C₃₀H₄₀N₂O₃
Molecular Weight:476.659
Hs Code.:

Synonyms:6-butyl-3-(4-ethoxyphenyl)-5-(4-hydroxy-3,5-dipropylbenzyl)-2-methylpyrimidin-4(3H)-one

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Chemical Property of 6-butyl-3-(4-ethoxyphenyl)-5-(4-hydroxy-3,5-dipropylbenzyl)-2-methylpyrimidin-4(3H)-one

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Technology Process of 6-butyl-3-(4-ethoxyphenyl)-5-(4-hydroxy-3,5-dipropylbenzyl)-2-methylpyrimidin-4(3H)-one

There total 6 articles about 6-butyl-3-(4-ethoxyphenyl)-5-(4-hydroxy-3,5-dipropylbenzyl)-2-methylpyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1256780-11-6
C₃₆H₅₄N₂O₃Si

: 1256780-12-7
6-butyl-3-(4-ethoxyphenyl)-5-(4-hydroxy-3,5-dipropylbenzyl)-2-methylpyrimidin-4(3H)-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h; cooling with ice;

Reference yield:

: 137421-55-7
t-butyl-dimethylsilyloxy-2,6-dipropyl-4-hydroxymethyl benzene

: 1256780-12-7
6-butyl-3-(4-ethoxyphenyl)-5-(4-hydroxy-3,5-dipropylbenzyl)-2-methylpyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: phosphorus tribromide / toluene / 1 h / 20 °C / cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 18 h / 20 °C

3.1: ammonium acetate; acetic acid / toluene / 5 h / Reflux

3.2: 14 h / 70 °C

4.1: trimethylaluminum / n-heptane; 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere

4.2: 15 h / 20 °C / Reflux

5.1: potassium carbonate / acetonitrile / 12 h / 60 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / cooling with ice

With ammonium acetate; tetrabutyl ammonium fluoride; trimethylaluminum; phosphorus tribromide; sodium hydride; potassium carbonate; acetic acid; In tetrahydrofuran; n-heptane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

Reference yield:

: 1256779-86-8
methyl 2-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-oxo heptanate

: 1256780-12-7
6-butyl-3-(4-ethoxyphenyl)-5-(4-hydroxy-3,5-dipropylbenzyl)-2-methylpyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium acetate; acetic acid / toluene / 5 h / Reflux

1.2: 14 h / 70 °C

2.1: trimethylaluminum / n-heptane; 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere

2.2: 15 h / 20 °C / Reflux

3.1: potassium carbonate / acetonitrile / 12 h / 60 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / cooling with ice

With ammonium acetate; tetrabutyl ammonium fluoride; trimethylaluminum; potassium carbonate; acetic acid; In tetrahydrofuran; n-heptane; 1,2-dichloro-ethane; toluene; acetonitrile;