methyl 3-acetamido-2-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-heptenate

Base Information

Chemical Name:methyl 3-acetamido-2-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-heptenate
CAS No.:1256779-87-9
Molecular Formula:C₂₉H₄₉NO₄Si
Molecular Weight:503.798
Hs Code.:

Synonyms:methyl 3-acetamido-2-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-heptenate

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Chemical Property of methyl 3-acetamido-2-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-heptenate

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Technology Process of methyl 3-acetamido-2-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-heptenate

There total 3 articles about methyl 3-acetamido-2-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-heptenate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.7%

: 1256779-86-8
methyl 2-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-oxo heptanate

: 108-24-7
acetic anhydride

: 1256779-87-9
methyl 3-acetamido-2-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-heptenate

Guidance literature:: methyl 2-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-oxo heptanate; With ammonium acetate; acetic acid; In toluene; for 5h; Reflux;

acetic anhydride; In acetic acid; at 70 ℃; for 14h;

Reference yield:

: 137421-55-7
t-butyl-dimethylsilyloxy-2,6-dipropyl-4-hydroxymethyl benzene

: 1256779-87-9
methyl 3-acetamido-2-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-heptenate

Guidance literature:: Multi-step reaction with 3 steps

1.1: phosphorus tribromide / toluene / 1 h / 20 °C / cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 18 h / 20 °C

3.1: ammonium acetate; acetic acid / toluene / 5 h / Reflux

3.2: 14 h / 70 °C

With ammonium acetate; phosphorus tribromide; sodium hydride; acetic acid; In N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 161922-06-1
4-(bromomethyl-2,6-diisopropylphenoxy)(tert-butyl)dimethylsilane

: 1256779-87-9
methyl 3-acetamido-2-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-heptenate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 18 h / 20 °C

2.1: ammonium acetate; acetic acid / toluene / 5 h / Reflux

2.2: 14 h / 70 °C

With ammonium acetate; sodium hydride; acetic acid; In N,N-dimethyl-formamide; toluene; mineral oil;