N-(4-fluoro-2-methoxy-6-(4-methyl-2-(3-methylpyridin-4-yl)-1H-imidazol-1-yl)phenyl)acetamide

Base Information

Chemical Name:N-(4-fluoro-2-methoxy-6-(4-methyl-2-(3-methylpyridin-4-yl)-1H-imidazol-1-yl)phenyl)acetamide
CAS No.:1159795-37-5
Molecular Formula:C₁₉H₁₉FN₄O₂
Molecular Weight:354.384
Hs Code.:

Synonyms:N-(4-fluoro-2-methoxy-6-(4-methyl-2-(3-methylpyridin-4-yl)-1H-imidazol-1-yl)phenyl)acetamide

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Chemical Property of N-(4-fluoro-2-methoxy-6-(4-methyl-2-(3-methylpyridin-4-yl)-1H-imidazol-1-yl)phenyl)acetamide

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Technology Process of N-(4-fluoro-2-methoxy-6-(4-methyl-2-(3-methylpyridin-4-yl)-1H-imidazol-1-yl)phenyl)acetamide

There total 6 articles about N-(4-fluoro-2-methoxy-6-(4-methyl-2-(3-methylpyridin-4-yl)-1H-imidazol-1-yl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₁₇FN₄O

: 108-24-7
acetic anhydride

: 1159795-37-5
N-(4-fluoro-2-methoxy-6-(4-methyl-2-(3-methylpyridin-4-yl)-1H-imidazol-1-yl)phenyl)acetamide

Guidance literature:: In toluene; at 80 ℃; for 4h;

Reference yield:

: 66684-61-5
1,5-difluoro-3-methoxy-2-nitrobenzene

: 1159795-37-5
N-(4-fluoro-2-methoxy-6-(4-methyl-2-(3-methylpyridin-4-yl)-1H-imidazol-1-yl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 8 h / 90 °C / Inert atmosphere

3: palladium 10% on activated carbon; ammonium formate / tetrahydrofuran; methanol / 2 h / 50 °C / Inert atmosphere

4: toluene / 4 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; ammonium formate; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm2009138

Reference yield:

: 1159795-35-3
2-bromo-1-(5-fluoro-3-methoxy-2-nitrophenyl)-4-methyl-1H-imidazole

: 1159795-37-5
N-(4-fluoro-2-methoxy-6-(4-methyl-2-(3-methylpyridin-4-yl)-1H-imidazol-1-yl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 8 h / 90 °C / Inert atmosphere

2: palladium 10% on activated carbon; ammonium formate / tetrahydrofuran; methanol / 2 h / 50 °C / Inert atmosphere

3: toluene / 4 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; ammonium formate; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; water; toluene;
DOI:10.1021/jm2009138