4-(1-(5-fluoro-3-methoxy-2-nitrophenyl)-4-methyl-1H-imidazol-2-yl)-3-methylpyridine

Base Information

Chemical Name:4-(1-(5-fluoro-3-methoxy-2-nitrophenyl)-4-methyl-1H-imidazol-2-yl)-3-methylpyridine
CAS No.:1159795-36-4
Molecular Formula:C₁₇H₁₅FN₄O₃
Molecular Weight:342.33
Hs Code.:

Synonyms:4-(1-(5-fluoro-3-methoxy-2-nitrophenyl)-4-methyl-1H-imidazol-2-yl)-3-methylpyridine

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Chemical Property of 4-(1-(5-fluoro-3-methoxy-2-nitrophenyl)-4-methyl-1H-imidazol-2-yl)-3-methylpyridine

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Technology Process of 4-(1-(5-fluoro-3-methoxy-2-nitrophenyl)-4-methyl-1H-imidazol-2-yl)-3-methylpyridine

There total 3 articles about 4-(1-(5-fluoro-3-methoxy-2-nitrophenyl)-4-methyl-1H-imidazol-2-yl)-3-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1159795-35-3
2-bromo-1-(5-fluoro-3-methoxy-2-nitrophenyl)-4-methyl-1H-imidazole

: 894808-72-1
(3-methylpyridin-4-yl)boronic acid

: 1159795-36-4
4-(1-(5-fluoro-3-methoxy-2-nitrophenyl)-4-methyl-1H-imidazol-2-yl)-3-methylpyridine

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 90 ℃; for 8h;

Reference yield:

: 66684-61-5
1,5-difluoro-3-methoxy-2-nitrobenzene

: 1159795-36-4
4-(1-(5-fluoro-3-methoxy-2-nitrophenyl)-4-methyl-1H-imidazol-2-yl)-3-methylpyridine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 8 h / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm2009138

Reference yield:

: 93343-10-3
3,5-difluoroanisol

: 1159795-36-4
4-(1-(5-fluoro-3-methoxy-2-nitrophenyl)-4-methyl-1H-imidazol-2-yl)-3-methylpyridine

Guidance literature:: Multi-step reaction with 3 steps

1: nitric acid / dichloromethane; water / 3 h / 0 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 8 h / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; nitric acid; potassium carbonate; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm2009138