(3S,4S,5E,8S)-4,8-dimethyl-9-[(1-phenyl-1H-tetrazol-5-yl)sulfonyl]non-5-en-3-ol

Base Information

Chemical Name:(3S,4S,5E,8S)-4,8-dimethyl-9-[(1-phenyl-1H-tetrazol-5-yl)sulfonyl]non-5-en-3-ol
CAS No.:934497-74-2
Molecular Formula:C₁₈H₂₆N₄O₃S
Molecular Weight:378.495
Hs Code.:

Synonyms:(3S,4S,5E,8S)-4,8-dimethyl-9-[(1-phenyl-1H-tetrazol-5-yl)sulfonyl]non-5-en-3-ol

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Chemical Property of (3S,4S,5E,8S)-4,8-dimethyl-9-[(1-phenyl-1H-tetrazol-5-yl)sulfonyl]non-5-en-3-ol

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Technology Process of (3S,4S,5E,8S)-4,8-dimethyl-9-[(1-phenyl-1H-tetrazol-5-yl)sulfonyl]non-5-en-3-ol

There total 5 articles about (3S,4S,5E,8S)-4,8-dimethyl-9-[(1-phenyl-1H-tetrazol-5-yl)sulfonyl]non-5-en-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 5-({(2S,4E,6S,7S)-2,6-dimethyl-7-[(triethylsilyl)oxy]non-4-en-1-yl}thio)-1-phenyl-1H-tetrazole

: 934497-74-2
(3S,4S,5E,8S)-4,8-dimethyl-9-[(1-phenyl-1H-tetrazol-5-yl)sulfonyl]non-5-en-3-ol

Guidance literature:: With ammonium molybdate; dihydrogen peroxide; In ethanol; at 20 ℃; for 24h;
DOI:10.1002/anie.200604997

Reference yield:

: 1399680-07-9
(2S,6S,7S,E)-2,6-dimethyl-7-((triethylsilyl)oxy)non-4-en-1-yl methanesulfonate

: 934497-74-2
(3S,4S,5E,8S)-4,8-dimethyl-9-[(1-phenyl-1H-tetrazol-5-yl)sulfonyl]non-5-en-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / 60 °C / Inert atmosphere

2: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / ethanol

With hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide; sodium hydride; In tetrahydrofuran; ethanol;
DOI:10.1021/ol301886g

Reference yield:

: 1399679-64-1
(S)-2-methylpent-4-en-1-yl methanesulfonate

: 934497-74-2
(3S,4S,5E,8S)-4,8-dimethyl-9-[(1-phenyl-1H-tetrazol-5-yl)sulfonyl]non-5-en-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; copper(l) iodide / diethyl ether / 3 h / 35 °C / Inert atmosphere

2: 1H-imidazole; dmap / dichloromethane / 4 h / 23 °C / Inert atmosphere

3: sodium hydride / tetrahydrofuran / 60 °C / Inert atmosphere

4: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / ethanol

With 1H-imidazole; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; dmap; copper(l) iodide; hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide; sodium hydride; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/ol301886g