Chemical Property of Hederagenin
Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Melting Point:332 - 334oC
- Refractive Index:1.569
- Boiling Point:589.4 °C at 760 mmHg
- PKA:4.63±0.70(Predicted)
- Flash Point:324.3 °C
- PSA：77.76000
- Density:1.14 g/cm3
- LogP:6.20600
- Storage Temp.:2-8°C
- Solubility.:methanol: soluble1mg/mL
- XLogP3:6.8
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:2
- Exact Mass:472.35526001
- Heavy Atom Count:34
- Complexity:908
- Purity/Quality:
-
≥98% *data from raw suppliers
Hederagenin *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
22
- Safety Statements:
22-45-24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)CO)O)C)C)C2C1)C)C(=O)O)C
- Isomeric SMILES:C[C@]12CC[C@@H]([C@@]([C@@H]1CC[C@@]3([C@@H]2CC=C4[C@]3(CC[C@@]5([C@H]4CC(CC5)(C)C)C(=O)O)C)C)(C)CO)O
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Description
Hederagenin is a triterpene saponin that has been found in P. eximia with diverse biological activities. It increases production of reactive oxygen species (ROS), reduces colony formation, and induces apoptosis in cisplatin-resistant head and neck carcinoma (HNC) cells. In vivo, hederagenin (50, 100, and 200 mg/kg) suppresses tumor growth in a cisplatin-resistant HNC mouse xenograft model. It reduces aortic atherosclerotic lesion area, serum cholesterol and LDL levels, and inducible nitric oxide synthase (iNOS) protein levels in a rat model of atherosclerosis. Hederagenin (50 mg/kg) reduces ethanol-induced production of TNF-α, IL-6, and COX-2, alcohol dehydrogenase 2 (ALDH2) mRNA expression, and liver damage in a rat model of alcohol-induced hepatotoxicity. It also induces autophagy and inhibits oligomerization of α-synuclein in a mouse model of Parkinson''s disease induced by MPTP.
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Uses
Triterpenoid which can inhibit the proliferation of leukemia HL-60 cells.
