trifluoro-methanesulfonic acid 2-{benzyl-[2-(benzyl-phenyl-carbamoyl)-cyclohexa-1,4-dienecarbonyl]-amino}-phenyl ester

Base Information

Chemical Name:trifluoro-methanesulfonic acid 2-{benzyl-[2-(benzyl-phenyl-carbamoyl)-cyclohexa-1,4-dienecarbonyl]-amino}-phenyl ester
CAS No.:881653-63-0
Molecular Formula:C₃₅H₂₉F₃N₂O₅S
Molecular Weight:646.687
Hs Code.:

Synonyms:trifluoro-methanesulfonic acid 2-{benzyl-[2-(benzyl-phenyl-carbamoyl)-cyclohexa-1,4-dienecarbonyl]-amino}-phenyl ester

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Chemical Property of trifluoro-methanesulfonic acid 2-{benzyl-[2-(benzyl-phenyl-carbamoyl)-cyclohexa-1,4-dienecarbonyl]-amino}-phenyl ester

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Technology Process of trifluoro-methanesulfonic acid 2-{benzyl-[2-(benzyl-phenyl-carbamoyl)-cyclohexa-1,4-dienecarbonyl]-amino}-phenyl ester

There total 8 articles about trifluoro-methanesulfonic acid 2-{benzyl-[2-(benzyl-phenyl-carbamoyl)-cyclohexa-1,4-dienecarbonyl]-amino}-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 881653-61-8
cyclohexa-1,4-diene-1,2-dicarboxylic acid 1-{benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-amide} 2-(benzyl-phenyl-amide)

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 881653-63-0
trifluoro-methanesulfonic acid 2-{benzyl-[2-(benzyl-phenyl-carbamoyl)-cyclohexa-1,4-dienecarbonyl]-amino}-phenyl ester

Guidance literature:: With caesium carbonate; cesium fluoride; In N,N-dimethyl-formamide; for 1h;
DOI:10.1021/jo052335a

Reference yield:

: 881653-53-8
propynoic acid benzyl-phenyl-amide

: 881653-63-0
trifluoro-methanesulfonic acid 2-{benzyl-[2-(benzyl-phenyl-carbamoyl)-cyclohexa-1,4-dienecarbonyl]-amino}-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

1.2: tetrahydrofuran; hexane / -78 - 20 °C

2.1: 19.6 g / 1-ethyl-3-(3'-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂ / -60 - -5 °C

3.1: 89 percent / 2,6-di-tert-butyl-4-methylpyridine; EtAlCl₂ / toluene; hexane / 48 h

4.1: 96 percent / cesium fluoride; cesium carbonate / dimethylformamide / 1 h

With n-butyllithium; 2,6-di-tert-butyl-4-methylpyridine; ethylaluminum dichloride; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; cesium fluoride; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; 3.1: Diels-Alder reaction;
DOI:10.1021/jo052335a

Reference yield:

: 881653-55-0
(benzyl-phenyl-carbamoyl)-propynoic acid

: 881653-63-0
trifluoro-methanesulfonic acid 2-{benzyl-[2-(benzyl-phenyl-carbamoyl)-cyclohexa-1,4-dienecarbonyl]-amino}-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 19.6 g / 1-ethyl-3-(3'-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂ / -60 - -5 °C

2: 89 percent / 2,6-di-tert-butyl-4-methylpyridine; EtAlCl₂ / toluene; hexane / 48 h

3: 96 percent / cesium fluoride; cesium carbonate / dimethylformamide / 1 h

With 2,6-di-tert-butyl-4-methylpyridine; ethylaluminum dichloride; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; cesium fluoride; In hexane; dichloromethane; N,N-dimethyl-formamide; toluene; 2: Diels-Alder reaction;
DOI:10.1021/jo052335a