2-(4-(N-(6-chloro-(2-hydroxyethoxy)-5-(4-methylphenyl)-4-pyrimidinyl)sulfamoyl)phenyl)-2-methylpropionic acid

Base Information

Chemical Name:2-(4-(N-(6-chloro-(2-hydroxyethoxy)-5-(4-methylphenyl)-4-pyrimidinyl)sulfamoyl)phenyl)-2-methylpropionic acid
CAS No.:169677-37-6
Molecular Formula:C₂₃H₂₅N₃O₆S
Molecular Weight:471.534
Hs Code.:

Synonyms:2-(4-(N-(6-chloro-(2-hydroxyethoxy)-5-(4-methylphenyl)-4-pyrimidinyl)sulfamoyl)phenyl)-2-methylpropionic acid

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Chemical Property of 2-(4-(N-(6-chloro-(2-hydroxyethoxy)-5-(4-methylphenyl)-4-pyrimidinyl)sulfamoyl)phenyl)-2-methylpropionic acid

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Technology Process of 2-(4-(N-(6-chloro-(2-hydroxyethoxy)-5-(4-methylphenyl)-4-pyrimidinyl)sulfamoyl)phenyl)-2-methylpropionic acid

There total 5 articles about 2-(4-(N-(6-chloro-(2-hydroxyethoxy)-5-(4-methylphenyl)-4-pyrimidinyl)sulfamoyl)phenyl)-2-methylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 107-21-1
ethylene glycol

: 374067-97-7
2-(4-(N-(6-chloro-5-(4-methylphenyl)-4-pyrimidinyl)sulfamoyl)phenyl)-2-methylpropionic acid

: 169677-37-6
2-(4-(N-(6-chloro-(2-hydroxyethoxy)-5-(4-methylphenyl)-4-pyrimidinyl)sulfamoyl)phenyl)-2-methylpropionic acid

Guidance literature:: With sodium hydride; at 110 ℃; for 48h;
DOI:10.1021/jm000538f

Reference yield:

: 2901-13-5
ethyl 2-methyl-2-phenylpropionate

: 169677-37-6
2-(4-(N-(6-chloro-(2-hydroxyethoxy)-5-(4-methylphenyl)-4-pyrimidinyl)sulfamoyl)phenyl)-2-methylpropionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: ClSO₃H / CH₂Cl₂ / 22 h / 20 °C

2: 1.56 g / aq. NH₄OH / ethyl acetate / 2 h / 20 °C

3: 94 percent / aq. NaOH / methanol / 22 h / 20 °C

4: 28 percent / NaH / dimethylsulfoxide / 22 h / 20 °C

5: 84 percent / NaH / 48 h / 110 °C

With chlorosulfonic acid; ammonium hydroxide; sodium hydroxide; sodium hydride; In methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jm000538f

Reference yield:

: 374067-95-5
2-methyl-2-(4-sulfamoylphenyl)propionic acid

: 169677-37-6
2-(4-(N-(6-chloro-(2-hydroxyethoxy)-5-(4-methylphenyl)-4-pyrimidinyl)sulfamoyl)phenyl)-2-methylpropionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 28 percent / NaH / dimethylsulfoxide / 22 h / 20 °C

2: 84 percent / NaH / 48 h / 110 °C

With sodium hydride; In dimethyl sulfoxide;
DOI:10.1021/jm000538f