N-(4-bromo-2-fluorophenyl)-6-methoxy-7-(piperidinyl-4-methoxy)quinazolin-4-amine hydrochloride

Base Information

Chemical Name:N-(4-bromo-2-fluorophenyl)-6-methoxy-7-(piperidinyl-4-methoxy)quinazolin-4-amine hydrochloride
CAS No.:1363151-84-1
Molecular Formula:C₂₁H₂₂BrFN₄O₂*ClH
Molecular Weight:497.795
Hs Code.:

Synonyms:N-(4-bromo-2-fluorophenyl)-6-methoxy-7-(piperidinyl-4-methoxy)quinazolin-4-amine hydrochloride

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Chemical Property of N-(4-bromo-2-fluorophenyl)-6-methoxy-7-(piperidinyl-4-methoxy)quinazolin-4-amine hydrochloride

Chemical Property:

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Technology Process of N-(4-bromo-2-fluorophenyl)-6-methoxy-7-(piperidinyl-4-methoxy)quinazolin-4-amine hydrochloride

There total 10 articles about N-(4-bromo-2-fluorophenyl)-6-methoxy-7-(piperidinyl-4-methoxy)quinazolin-4-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 338992-20-4
4-(((4-((4-bromo-2-fluorophenyl)amino)-6-methoxyquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylic acid tert-butyl ester

: 1363151-84-1
N-(4-bromo-2-fluorophenyl)-6-methoxy-7-(piperidinyl-4-methoxy)quinazolin-4-amine hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; hexane; ethyl acetate; at 20 ℃; for 10h;

Reference yield:

: 60547-92-4
4-(benzyloxy)-5-methoxy-2-nitrobenzoic acid

: 1363151-84-1
N-(4-bromo-2-fluorophenyl)-6-methoxy-7-(piperidinyl-4-methoxy)quinazolin-4-amine hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: oxalyl dichloride / toluene / 2 h / Reflux

1.2: 2 h

2.1: acetic acid / 0.17 h / 90 °C

2.2: 1 h / Reflux

3.1: 1,4-dioxane / 12 h / Reflux

3.2: 3 h / Reflux

4.1: thionyl chloride; trichlorophosphate / N,N-dimethyl-formamide / 2 h / Reflux

5.1: isopropyl alcohol / 2 h / Reflux

6.1: trifluoroacetic acid / 2 h / Heating

7.1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 3 h / 20 °C

8.1: hydrogenchloride / ethyl acetate; 1,4-dioxane; hexane / 10 h / 20 °C

With hydrogenchloride; thionyl chloride; oxalyl dichloride; di-isopropyl azodicarboxylate; acetic acid; triphenylphosphine; trifluoroacetic acid; trichlorophosphate; N,N-dimethyl-formamide; In 1,4-dioxane; hexane; dichloromethane; ethyl acetate; isopropyl alcohol; toluene;

Reference yield:

: 2426-84-8
4-(benzyloxy)-5-methoxy-2-nitrobenzaldehyde

: 1363151-84-1
N-(4-bromo-2-fluorophenyl)-6-methoxy-7-(piperidinyl-4-methoxy)quinazolin-4-amine hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium permanganate / acetone / 2 h / 30 - 50 °C

2.1: oxalyl dichloride / toluene / 2 h / Reflux

2.2: 2 h

3.1: acetic acid / 0.17 h / 90 °C

3.2: 1 h / Reflux

4.1: 1,4-dioxane / 12 h / Reflux

4.2: 3 h / Reflux

5.1: thionyl chloride; trichlorophosphate / N,N-dimethyl-formamide / 2 h / Reflux

6.1: isopropyl alcohol / 2 h / Reflux

7.1: trifluoroacetic acid / 2 h / Heating

8.1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 3 h / 20 °C

9.1: hydrogenchloride / ethyl acetate; 1,4-dioxane; hexane / 10 h / 20 °C

With hydrogenchloride; potassium permanganate; thionyl chloride; oxalyl dichloride; di-isopropyl azodicarboxylate; acetic acid; triphenylphosphine; trifluoroacetic acid; trichlorophosphate; N,N-dimethyl-formamide; In 1,4-dioxane; hexane; dichloromethane; ethyl acetate; isopropyl alcohol; acetone; toluene;