1-(2,5-dimethyl-2H-pyrazol-3-yl)-3-(2-hydroxy-2-p-tolylethyl)urea

Base Information

• Chemical Name: 1-(2,5-dimethyl-2H-pyrazol-3-yl)-3-(2-hydroxy-2-p-tolylethyl)urea
• CAS No.: 1223271-54-2
• Molecular Formula: C₁₅H₂₀N₄O₂
• Molecular Weight: 288.349
• Mol file: 1223271-54-2.mol

Synonyms:1-(2,5-dimethyl-2H-pyrazol-3-yl)-3-(2-hydroxy-2-p-tolylethyl)urea

Chemical Property of 1-(2,5-dimethyl-2H-pyrazol-3-yl)-3-(2-hydroxy-2-p-tolylethyl)urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2,5-dimethyl-2H-pyrazol-3-yl)-3-(2-hydroxy-2-p-tolylethyl)urea

There total 3 articles about 1-(2,5-dimethyl-2H-pyrazol-3-yl)-3-(2-hydroxy-2-p-tolylethyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(2,5-dimethyl-2H-pyrazol-3-yl)carbamic acid 2,2,2-trifluoroethyl ester (1197480-43-5) + 2-amino-1-(4-methylphenyl)ethanol (53360-85-3) → 1-(2,5-dimethyl-2H-pyrazol-3-yl)-3-(2-hydroxy-2-p-tolylethyl)urea (1223271-54-2)

Guidance literature:

In acetonitrile; at 100 ℃; for 4h;

DOI:10.1016/j.tet.2011.03.101

Reference yield:

5-Amino-1,3-dimethylpyrazole (3524-32-1) → 1-(2,5-dimethyl-2H-pyrazol-3-yl)-3-(2-hydroxy-2-p-tolylethyl)urea (1223271-54-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / acetonitrile / 20 - 30 °C

2: acetonitrile / 4 h / 100 °C

With triethylamine; In acetonitrile;

DOI:10.1016/j.tet.2011.03.101

Reference yield:

C6H7N3O (785781-34-2) → 1-(2,5-dimethyl-2H-pyrazol-3-yl)-3-(2-hydroxy-2-p-tolylethyl)urea (1223271-54-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / hexane; toluene / 4 h / Reflux

2: acetonitrile / 4 h / 100 °C

With triethylamine; In hexane; toluene; acetonitrile;

DOI:10.1016/j.tet.2011.03.101

upstream raw materials:

5-Amino-1,3-dimethylpyrazole

(2,5-dimethyl-2H-pyrazol-3-yl)carbamic acid 2,2,2-trifluoroethyl ester

2-amino-1-(4-methylphenyl)ethanol

C₆H₇N₃O