4-[4-(methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidine-2-yl]aniline

Base Information

• Chemical Name: 4-[4-(methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidine-2-yl]aniline
• CAS No.: 944058-10-0
• Molecular Formula: C₁₆H₂₀N₄O₃S
• Molecular Weight: 348.426
• Mol file: 944058-10-0.mol

Synonyms:4-[4-(methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidine-2-yl]aniline

Chemical Property of 4-[4-(methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidine-2-yl]aniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[4-(methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidine-2-yl]aniline

There total 4 articles about 4-[4-(methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidine-2-yl]aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

C21H28N4O5S (1394254-56-8) → 4-[4-(methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidine-2-yl]aniline (944058-10-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 4h;

DOI:10.1016/j.bmcl.2012.04.036

Reference yield:

4-(6-(methylsulfonylmethyl)-2-(methylthio)pyrimidin-4-yl)morpholine (944058-81-5) + (4-aminophenyl)boronic acid (89415-43-0) → 4-[4-(methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidine-2-yl]aniline (944058-10-0)

Guidance literature:

With copper(I) thiophene-2-carboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 130 ℃; for 1h; Microwave irradiation;

Reference yield:

2-methylsulfanyl-6-(methylsulfonylmethyl)pyrimidin-4-ol → 4-[4-(methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidine-2-yl]aniline (944058-10-0)

Guidance literature:

Multi-step reaction with 4 steps

1: trichlorophosphate / 1 h / Reflux

2: dichloromethane / 18 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) thiophene-2-carboxylate / 1,4-dioxane / 2.5 h / 101 °C

4: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) thiophene-2-carboxylate; trichlorophosphate; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.bmcl.2012.04.036

upstream raw materials:

4-(6-(methylsulfonylmethyl)-2-(methylthio)pyrimidin-4-yl)morpholine

(4-aminophenyl)boronic acid

C₂₁H₂₈N₄O₅S

Downstream raw materials:

N-[4-[4-(methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidin-2-yl]phenyl]acetamide

N-[4-[4-(methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidin-2-yl]phenyl]cyclobutanecarboxamide

N-[4-[4-(methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidin-2-yl]phenyl]-1,2-oxazole-5-carboxamide

C₂₃H₂₄FN₅O₄S