methyl 1-{[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]-acetyl}-L-prolinate

Base Information

Chemical Name:methyl 1-{[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]-acetyl}-L-prolinate
CAS No.:851586-54-4
Molecular Formula:C₃₁H₄₃N₃O₅
Molecular Weight:537.7
Hs Code.:

Synonyms:methyl 1-{[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]-acetyl}-L-prolinate

Suppliers and Price of methyl 1-{[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]-acetyl}-L-prolinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 1-{[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]-acetyl}-L-prolinate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 1-{[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]-acetyl}-L-prolinate

There total 12 articles about methyl 1-{[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]-acetyl}-L-prolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 851577-69-0
[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]acetic acid

: 2577-48-2
methyl (2S)-pyrrolidine carboxylate

: 851586-54-4
methyl 1-{[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]-acetyl}-L-prolinate

Guidance literature:: With HATU; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmc.2010.11.038

Reference yield:

: 907611-08-9
5-methyl-2-[(4-methylphenyl)methylidene]-3-oxohexanenitrile

: 851586-54-4
methyl 1-{[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]-acetyl}-L-prolinate

Guidance literature:: Multi-step reaction with 10 steps

1.1: methanol / 4 h / 80 °C

2.1: nitric acid / 1,4-dioxane / 0.75 h / 75 - 80 °C

3.1: ammonia; hydrogen / methanol; water / 5 h / 40 °C / 3750.38 Torr / Sealed tube

4.1: diisobutylaluminium hydride / toluene / -78 - 0 °C

4.2: 0 - 20 °C

5.1: sodium hydroxide / water; ethyl acetate; acetone; toluene / 0.5 h / 20 °C

6.1: triethylamine / tetrahydrofuran / 0.5 h / 0 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran; acetonitrile / 1 h / 20 °C

8.1: hydrogenchloride; water / 20 h / 90 °C

9.1: sodium hydroxide / water / pH 8

9.2: 1 h / 20 °C

10.1: HATU / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; tetrabutyl ammonium fluoride; ammonia; water; hydrogen; nitric acid; diisobutylaluminium hydride; triethylamine; HATU; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.1016/j.bmc.2010.11.038

Reference yield:

: 851577-39-4
methyl 5-cyano-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)-1,4-dihydropyridine-3-carboxylate

: 851586-54-4
methyl 1-{[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]-acetyl}-L-prolinate

Guidance literature:: Multi-step reaction with 9 steps

1.1: nitric acid / 1,4-dioxane / 0.75 h / 75 - 80 °C

2.1: ammonia; hydrogen / methanol; water / 5 h / 40 °C / 3750.38 Torr / Sealed tube

3.1: diisobutylaluminium hydride / toluene / -78 - 0 °C

3.2: 0 - 20 °C

4.1: sodium hydroxide / water; ethyl acetate; acetone; toluene / 0.5 h / 20 °C

5.1: triethylamine / tetrahydrofuran / 0.5 h / 0 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran; acetonitrile / 1 h / 20 °C

7.1: hydrogenchloride; water / 20 h / 90 °C

8.1: sodium hydroxide / water / pH 8

8.2: 1 h / 20 °C

9.1: HATU / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; tetrabutyl ammonium fluoride; ammonia; water; hydrogen; nitric acid; diisobutylaluminium hydride; triethylamine; HATU; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.1016/j.bmc.2010.11.038