4-(benzylamino)-6-{[4-(morpholinomethyl)phenyl]amino}pyridine-3-carboxyamide

Base Information

Chemical Name:4-(benzylamino)-6-{[4-(morpholinomethyl)phenyl]amino}pyridine-3-carboxyamide
CAS No.:1227865-71-5
Molecular Formula:C₂₄H₂₇N₅O₂
Molecular Weight:417.511
Hs Code.:

Synonyms:4-(benzylamino)-6-{[4-(morpholinomethyl)phenyl]amino}pyridine-3-carboxyamide

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Chemical Property of 4-(benzylamino)-6-{[4-(morpholinomethyl)phenyl]amino}pyridine-3-carboxyamide

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Technology Process of 4-(benzylamino)-6-{[4-(morpholinomethyl)phenyl]amino}pyridine-3-carboxyamide

There total 4 articles about 4-(benzylamino)-6-{[4-(morpholinomethyl)phenyl]amino}pyridine-3-carboxyamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 51013-67-3
4-morpholinomethyl aniline

: 1227861-73-5
4-(benzylamino)-6-chloronicotinamide

: 1227865-71-5
4-(benzylamino)-6-{[4-(morpholinomethyl)phenyl]amino}pyridine-3-carboxyamide

Guidance literature:: With sodium t-butanolate; 1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 100 ℃; for 3h; Inert atmosphere;

Reference yield:

: 70593-57-6
4,6-dichloro-nicotinamide

: 1227865-71-5
4-(benzylamino)-6-{[4-(morpholinomethyl)phenyl]amino}pyridine-3-carboxyamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / ethanol / 12 h / Reflux

2: sodium t-butanolate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis-(diphenylphosphino)ferrocene / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; sodium t-butanolate; 1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; ethanol;

Reference yield:

: 100-46-9
benzylamine

: 1227865-71-5
4-(benzylamino)-6-{[4-(morpholinomethyl)phenyl]amino}pyridine-3-carboxyamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / ethanol / 12 h / Reflux

2: sodium t-butanolate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis-(diphenylphosphino)ferrocene / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; sodium t-butanolate; 1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; ethanol;