70593-57-6

Basic information

• Product Name: 4,6-DICHLORO-NICOTINAMIDE
• Synonyms: 4,6-DICHLORO-NICOTINAMIDE;4,6-DICHLOROPYRIDINE-3-CARBOXAMIDE;3-Pyridinecarboxamide, 4,6-dichloro-;4,6-DICHLORONICOTINAMIDE >95%
• CAS NO: 70593-57-6
• Molecular Formula: C₆H₄Cl₂N₂O
• Molecular Weight: 191.01
• Product Categories: Pyridines
• Mol File: 70593-57-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 153-155°
• Boiling Point: 302.9 °C at 760 mmHg
• Flash Point: 137 °C
• Appearance: /
• Density: 1.524
• Vapor Pressure: 0.000965mmHg at 25°C
• Refractive Index: 1.603
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 13.91±0.50(Predicted)
• CAS DataBase Reference: 4,6-DICHLORO-NICOTINAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-DICHLORO-NICOTINAMIDE(70593-57-6)
• EPA Substance Registry System: 4,6-DICHLORO-NICOTINAMIDE(70593-57-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 70593-57-6(Hazardous Substances Data)

Usage

Uses

4,6-Dichloronicotinamide

InChI:InChI=1/C6H4Cl2N2O/c7-4-1-5(8)10-2-3(4)6(9)11/h1-2H,(H2,9,11)

Upstream product

• 5466-62-6 4,6-dihydroxy-nicotinic acid 
• 40296-46-6 ethyl 4,6-dichloronicotinate 
• 107836-75-9 4,6-dichloropyridine-3-carbonyl chloride 
• 65973-52-6 methyl 4,6-dichloropyridine-3-carboxylate 
• 73027-79-9 4,6-dichloro-nicotinic acid 
• 7664-41-7 ammonia 
• 2592-95-2 benzotriazol-1-ol 

Downstream Products

• 1254216-71-1 6-(4-fluoro-3-(pyrrolidine-1-carboxamido)phenylamino)-4-(pyridin-3-ylmethylamino)nicotinamide 
• 1374211-57-0 4-(1-phenylcyclopropylamino)-6-(4-(4-propionylpiperazin-1-yl)phenylamino)nicotinamide 
• 1374212-53-9 4-(3-(1H-imidazol-1-yl)benzylamino)-6-(4-(dimethylcarbamoyl)phenylamino)nicotinamide 
• 1374213-82-7 4-(1-phenylcyclopropylamino)-6-(3-(piperazin-1-yl)phenylamino)nicotinamide 
• 1374213-83-8 6-(3-(4-acetylpiperazin-1-yl)phenylamino)-4-(1-phenylcyclopropylamino)nicotinamide 
• 1374215-25-4 4-(3-(1H-imidazol-1-yl)benzylamino)-6-chloronicotinamide 
• 1374211-55-8 6-(4-(4-acetylpiperazin-1-yl)phenylamino)-4-(thiophen-2-ylmethylamino)nicotinamide 
• 1374212-52-8 6-(3-acetamidophenylamino)-4-(thiophen-2-ylmethylamino)nicotinamide 
• 1374215-26-5 C₃₀H₃₆N₆O₃ 
• 1374215-15-2 6-chloro-4-(1-phenylcyclopropylamino)nicotinamide 
• 1374215-24-3 6-chloro-4-(3-iodobenzylamino)nicotinamide 
• 1227862-12-5 6-chloro-4-[(2,5-difluorobenzyl)amino]pyridine-3-carboxyamide 
• 1227862-29-4 6-chloro-4-(3-nitrobenzylamino)nicotinamide 

Relevant articles and documents

AMIDE-SUBSTITUTED HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CONDITIONS RELATED TO THE MODULATION OF IL-12, IL-23 AND/OR IFN-ALPHA

Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-2

Boron-Containing Small Molecules as Anti-Inflammatory Agents

Compounds and methods of treating anti-inflammatory conditions are disclosed.

4,6-DIAMINONICOTINAMIDE COMPOUND

[Problem] The present invention provides a 4,6-diaminonicotinamide compound which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for treating diseases caused by undesirable and/or abnormal cytokine signal transduction. [Means for Solution] The present inventors have extensively studied compounds having a JAK3 inhibitory action, and as a result, they have found that a 4,6-diaminonicotinamide compound which is the compound of the present invention has an excellent JAK3 inhibitory action and is useful as an agent for preventing or treating diseases caused by undesirable and/or abnormal cytokine signal transduction, thereby completing the present invention.