2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-phenylamino-2H-pyridazin-3-one

Base Information

Chemical Name:2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-phenylamino-2H-pyridazin-3-one
CAS No.:1234349-52-0
Molecular Formula:C₂₆H₂₈N₆O₂
Molecular Weight:456.547
Hs Code.:

Synonyms:2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-phenylamino-2H-pyridazin-3-one

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Chemical Property of 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-phenylamino-2H-pyridazin-3-one

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Technology Process of 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-phenylamino-2H-pyridazin-3-one

There total 11 articles about 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-phenylamino-2H-pyridazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1092568-89-2
{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]phenyl}-methanol

: 1496-84-0
6-anilino-2H-pyridazin-3-one

: 1234349-52-0
2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-phenylamino-2H-pyridazin-3-one

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 2h; Cooling with ice;

Reference yield:

: 264264-32-6
3-(5-methyl-[1,2,4]-oxadiazol-3-yl)benzoic acid

: 1234349-52-0
2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-phenylamino-2H-pyridazin-3-one

Guidance literature:: Multi-step reaction with 8 steps

1: sulfuric acid / 18 h / Reflux

2: hydrogen; water; acetic acid / Raney nickel / methanol / 18 h / 20 °C / 760.05 Torr

3: sodium methylate / methanol / 1.17 h / 60 °C

4: water; sulfuric acid / 4 h / Reflux

5: thionyl chloride / 6 h / 80 °C

6: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Cooling with ice

7: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

8: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

With thionyl chloride; di-isopropyl azodicarboxylate; sulfuric acid; water; hydrogen; sodium methylate; diisobutylaluminium hydride; acetic acid; triphenylphosphine; Raney nickel; In tetrahydrofuran; methanol;

Reference yield:

: 1092566-65-8
methyl 3-(5-methyl-1,2,4-oxadiazol-3-yl)benzoate

: 1234349-52-0
2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-phenylamino-2H-pyridazin-3-one

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogen; water; acetic acid / Raney nickel / methanol / 18 h / 20 °C / 760.05 Torr

2: sodium methylate / methanol / 1.17 h / 60 °C

3: water; sulfuric acid / 4 h / Reflux

4: thionyl chloride / 6 h / 80 °C

5: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Cooling with ice

6: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

7: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

With thionyl chloride; di-isopropyl azodicarboxylate; sulfuric acid; water; hydrogen; sodium methylate; diisobutylaluminium hydride; acetic acid; triphenylphosphine; Raney nickel; In tetrahydrofuran; methanol;