4-(4cCyanophenyl)-2,5-dioxo-N-(1,1-dioxo-1λ⁶-thietan-3-yl)-1-(3-(trifluoromethyl)-phenyl)-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidine-3(2H)-carboxamide

Base Information

• Chemical Name: 4-(4cCyanophenyl)-2,5-dioxo-N-(1,1-dioxo-1λ⁶-thietan-3-yl)-1-(3-(trifluoromethyl)-phenyl)-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidine-3(2H)-carboxamide
• CAS No.: 1621271-87-1
• Molecular Formula: C₂₅H₁₉F₃N₄O₅S
• Molecular Weight: 544.511

Synonyms:4-(4cCyanophenyl)-2,5-dioxo-N-(1,1-dioxo-1λ⁶-thietan-3-yl)-1-(3-(trifluoromethyl)-phenyl)-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidine-3(2H)-carboxamide

Chemical Property of 4-(4cCyanophenyl)-2,5-dioxo-N-(1,1-dioxo-1λ⁶-thietan-3-yl)-1-(3-(trifluoromethyl)-phenyl)-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidine-3(2H)-carboxamide

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Technology Process of 4-(4cCyanophenyl)-2,5-dioxo-N-(1,1-dioxo-1λ⁶-thietan-3-yl)-1-(3-(trifluoromethyl)-phenyl)-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidine-3(2H)-carboxamide

There total 12 articles about 4-(4cCyanophenyl)-2,5-dioxo-N-(1,1-dioxo-1λ⁶-thietan-3-yl)-1-(3-(trifluoromethyl)-phenyl)-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidine-3(2H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-dioxo-1λ6-thiethan-3-amine hydrochloride (1422344-24-8) + 4-(2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-2,3,4,5,6,7-hexahydro-1H-cyclopenta[d]-pyrimidin-4-yl)benzonitrile (1621269-89-3) + 4-Nitrophenyl chloroformate (7693-46-1) → 4-(4cCyanophenyl)-2,5-dioxo-N-(1,1-dioxo-1λ6-thietan-3-yl)-1-(3-(trifluoromethyl)-phenyl)-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidine-3(2H)-carboxamide (1621271-87-1)

Guidance literature:

4-(2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-2,3,4,5,6,7-hexahydro-1H-cyclopenta[d]-pyrimidin-4-yl)benzonitrile; 4-Nitrophenyl chloroformate; With dmap; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;

1,1-dioxo-1λ⁶-thiethan-3-amine hydrochloride; In acetonitrile; for 1h;

Reference yield:

1,1-dioxo-1λ6-thiethan-3-amine hydrochloride (1422344-24-8) + 4-nitrophenyl 4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidine-3(2H)-carboxylate (1621272-86-3) → 4-(4cCyanophenyl)-2,5-dioxo-N-(1,1-dioxo-1λ6-thietan-3-yl)-1-(3-(trifluoromethyl)-phenyl)-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidine-3(2H)-carboxamide (1621271-87-1)

Guidance literature:

In acetonitrile; for 1h;

Reference yield:

3-[[3-(trifluoromethyl)phenyl]amino]-2-cyclopenten-1-one → 4-(4cCyanophenyl)-2,5-dioxo-N-(1,1-dioxo-1λ6-thietan-3-yl)-1-(3-(trifluoromethyl)-phenyl)-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidine-3(2H)-carboxamide (1621271-87-1)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 20 °C / Reflux

2: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 1 h

3: acetonitrile / 1 h

With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;

upstream raw materials:

diethyl (4-cyanophenyl)methylenedicarbamate

4-cyanobenzaldehyde

4-(chloro(isocyanato)methyl)benzonitrile

4-(4-bromophenyl)-1-(3-(trifluoromethyl)phenyl)-3,4,6,7-tetrahydro-1H-cyclo-penta[d]pyrimidine-2,5-dione

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