[4-(3,4-Dichloro-phenyl)-1H-pyrrol-3-yl]-(4-pyrrol-1-yl-phenyl)-methanone

Base Information

• Chemical Name: [4-(3,4-Dichloro-phenyl)-1H-pyrrol-3-yl]-(4-pyrrol-1-yl-phenyl)-methanone
• CAS No.: 170939-81-8
• Molecular Formula: C₂₁H₁₄Cl₂N₂O
• Molecular Weight: 381.261

Synonyms:[4-(3,4-Dichloro-phenyl)-1H-pyrrol-3-yl]-(4-pyrrol-1-yl-phenyl)-methanone

Chemical Property of [4-(3,4-Dichloro-phenyl)-1H-pyrrol-3-yl]-(4-pyrrol-1-yl-phenyl)-methanone

Chemical Property:

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Technology Process of [4-(3,4-Dichloro-phenyl)-1H-pyrrol-3-yl]-(4-pyrrol-1-yl-phenyl)-methanone

There total 3 articles about [4-(3,4-Dichloro-phenyl)-1H-pyrrol-3-yl]-(4-pyrrol-1-yl-phenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

[(p-methylphenyl)sulfonylmethyl]isonitrile (38622-91-2,36635-61-7) + (E)-3-(3,4-Dichloro-phenyl)-1-(4-pyrrol-1-yl-phenyl)-propenone → [4-(3,4-Dichloro-phenyl)-1H-pyrrol-3-yl]-(4-pyrrol-1-yl-phenyl)-methanone (170939-81-8)

Guidance literature:

With sodium hydride; In diethyl ether; dimethyl sulfoxide; for 0.416667h; Ambient temperature;

DOI:10.1021/jm00021a011

Reference yield:

4-(1H-pyrrol-1-yl)acetophenone (22106-37-2) → [4-(3,4-Dichloro-phenyl)-1H-pyrrol-3-yl]-(4-pyrrol-1-yl-phenyl)-methanone (170939-81-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent

2: 57 percent / NaH / dimethylsulfoxide; diethyl ether / 0.42 h / Ambient temperature

With sodium hydride; In diethyl ether; dimethyl sulfoxide;

DOI:10.1021/jm00021a011

Reference yield:

3,4-dichlorobenzaldehyde (6287-38-3) → [4-(3,4-Dichloro-phenyl)-1H-pyrrol-3-yl]-(4-pyrrol-1-yl-phenyl)-methanone (170939-81-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent

2: 57 percent / NaH / dimethylsulfoxide; diethyl ether / 0.42 h / Ambient temperature

With sodium hydride; In diethyl ether; dimethyl sulfoxide;

DOI:10.1021/jm00021a011

upstream raw materials:

[(p-methylphenyl)sulfonylmethyl]isonitrile

4-(1H-pyrrol-1-yl)acetophenone

3,4-dichlorobenzaldehyde

Downstream raw materials:

[4-(3,4-Dichloro-phenyl)-1H-pyrrol-3-yl]-(4-pyrrol-1-yl-phenyl)-methanol

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