Technology Process of ((1R,2R,6R)-2-Benzenesulfonylmethyl-6-isopropyl-3-methyl-cyclohex-3-enylmethoxy)-tert-butyl-dimethyl-silane
There total 11 articles about ((1R,2R,6R)-2-Benzenesulfonylmethyl-6-isopropyl-3-methyl-cyclohex-3-enylmethoxy)-tert-butyl-dimethyl-silane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 93 percent / H2; (PPh3)3RhCl / benzene
2: 61 percent / TiCl4; DIPEA / CH2Cl2 / -78 - 0 °C
3: 71 percent / tetrahydrofuran / 20 h / Heating
4: tetrahydrofuran / 20 h / 45 °C
5: 10.40 g / H2O2; NaOH / tetrahydrofuran; H2O / 1.25 h / 0 - 20 °C
6: 73 percent / Jones reagent / acetone / 11 h
7: 89 percent / dimethylformamide / 4 h / 110 °C
8: 24.16 g / K2CO3 / acetone / 1.5 h
9: 19.15 g / DIBAL-H / CH2Cl2 / -78 - 0 °C
10: 89 percent / Na2WO4*2H2O; H2O2; Aliquat 336 / CH2Cl2; H2O / 40 h / Heating
11: 96 percent / imidazole / dimethylformamide / 4 h
With
1H-imidazole; sodium hydroxide; sodium tungstate; Wilkinson's catalyst; jones reagent; hydrogen; dihydrogen peroxide; titanium tetrachloride; Aliquat 336; diisobutylaluminium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone; benzene;
1: Catalytic hydrogenation / 2: Alkylation / 3: methenylation / 4: Addition / 5: Oxidation / 6: Oxidation / 7: Ring cleavage / 8: Methylation / 9: Reduction / 10: Oxidation / 11: Condensation;
DOI:10.1016/S0040-4020(00)00309-4
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 61 percent / TiCl4; DIPEA / CH2Cl2 / -78 - 0 °C
2: 71 percent / tetrahydrofuran / 20 h / Heating
3: tetrahydrofuran / 20 h / 45 °C
4: 10.40 g / H2O2; NaOH / tetrahydrofuran; H2O / 1.25 h / 0 - 20 °C
5: 73 percent / Jones reagent / acetone / 11 h
6: 89 percent / dimethylformamide / 4 h / 110 °C
7: 24.16 g / K2CO3 / acetone / 1.5 h
8: 19.15 g / DIBAL-H / CH2Cl2 / -78 - 0 °C
9: 89 percent / Na2WO4*2H2O; H2O2; Aliquat 336 / CH2Cl2; H2O / 40 h / Heating
10: 96 percent / imidazole / dimethylformamide / 4 h
With
1H-imidazole; sodium hydroxide; sodium tungstate; jones reagent; dihydrogen peroxide; titanium tetrachloride; Aliquat 336; diisobutylaluminium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone;
1: Alkylation / 2: methenylation / 3: Addition / 4: Oxidation / 5: Oxidation / 6: Ring cleavage / 7: Methylation / 8: Reduction / 9: Oxidation / 10: Condensation;
DOI:10.1016/S0040-4020(00)00309-4
