Technology Process of 3-(aminomethyl)-6-chloro-2-propyl-4-phenylisoquinolin-1(2H)-one
There total 11 articles about 3-(aminomethyl)-6-chloro-2-propyl-4-phenylisoquinolin-1(2H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ammonia;
In
tetrahydrofuran; methanol;
at 150 ℃;
for 6h;
Sealed tube;
DOI:10.1016/j.bmc.2011.06.059
- Guidance literature:
-
Multi-step reaction with 7 steps
1: hydrogenchloride; water; acetic acid / 3 h / 110 °C
2: methanol / 15 h / 20 °C
3: hydrogenchloride / ethyl acetate / 3 h / 20 °C
4: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 20 °C
5: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 2 h / 0 °C
6: triethylamine / dichloromethane / 0.5 h / 20 °C
7: ammonia / tetrahydrofuran; methanol / 6 h / 150 °C / Sealed tube
With
hydrogenchloride; sodium tetrahydroborate; oxalyl dichloride; ammonia; water; acetic acid; triethylamine; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmc.2011.06.059
- Guidance literature:
-
Multi-step reaction with 5 steps
1: hydrogenchloride / ethyl acetate / 3 h / 20 °C
2: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 20 °C
3: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 2 h / 0 °C
4: triethylamine / dichloromethane / 0.5 h / 20 °C
5: ammonia / tetrahydrofuran; methanol / 6 h / 150 °C / Sealed tube
With
hydrogenchloride; sodium tetrahydroborate; oxalyl dichloride; ammonia; triethylamine; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmc.2011.06.059
