5-allyl 1-benzyl (2S)-2-[[(5-hydroxy-1,2-dimethyl-1H-indol-3-yl)carbonyl](methyl)amino]pentanedioate

Base Information

Chemical Name:5-allyl 1-benzyl (2S)-2-[[(5-hydroxy-1,2-dimethyl-1H-indol-3-yl)carbonyl](methyl)amino]pentanedioate
CAS No.:1266099-95-9
Molecular Formula:C₂₇H₃₀N₂O₆
Molecular Weight:478.545
Hs Code.:

Synonyms:5-allyl 1-benzyl (2S)-2-[[(5-hydroxy-1,2-dimethyl-1H-indol-3-yl)carbonyl](methyl)amino]pentanedioate

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Chemical Property of 5-allyl 1-benzyl (2S)-2-[[(5-hydroxy-1,2-dimethyl-1H-indol-3-yl)carbonyl](methyl)amino]pentanedioate

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Technology Process of 5-allyl 1-benzyl (2S)-2-[[(5-hydroxy-1,2-dimethyl-1H-indol-3-yl)carbonyl](methyl)amino]pentanedioate

There total 8 articles about 5-allyl 1-benzyl (2S)-2-[[(5-hydroxy-1,2-dimethyl-1H-indol-3-yl)carbonyl](methyl)amino]pentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1266099-94-8
C₂₉H₃₂N₂O₇

: 1266099-95-9
5-allyl 1-benzyl (2S)-2-[[(5-hydroxy-1,2-dimethyl-1H-indol-3-yl)carbonyl](methyl)amino]pentanedioate

Guidance literature:: With 1-amino-3-(dimethylamino)propane; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 132286-79-4,259221-91-5
N-α-(t-butoxycarbonyl)-L-glutamic γ-allyl ester

: 1266099-95-9
5-allyl 1-benzyl (2S)-2-[[(5-hydroxy-1,2-dimethyl-1H-indol-3-yl)carbonyl](methyl)amino]pentanedioate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 16 h / 20 °C

2.1: hydrogenchloride / 1,4-dioxane

3.1: pyridine / dichloromethane / 15 h / 0 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

5.1: thiophenol; caesium carbonate / acetonitrile / 16 h / 20 °C

5.2: 0.08 h

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C

7.1: 1-amino-3-(dimethylamino)propane / tetrahydrofuran / 16 h / 20 °C

With pyridine; hydrogenchloride; sodium hydrogencarbonate; caesium carbonate; thiophenol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-amino-3-(dimethylamino)propane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1264239-56-6
(S)-5-allyl 1-benzyl 2-(methylamino)pentanedioate hydrochloride

: 1266099-95-9
5-allyl 1-benzyl (2S)-2-[[(5-hydroxy-1,2-dimethyl-1H-indol-3-yl)carbonyl](methyl)amino]pentanedioate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C

2: 1-amino-3-(dimethylamino)propane / tetrahydrofuran / 16 h / 20 °C

With 1-amino-3-(dimethylamino)propane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;