1-(4-fluorophenyl)-2-nitroethanol

Base Information

• Chemical Name: 1-(4-fluorophenyl)-2-nitroethanol
• CAS No.: 1029598-42-2
• Molecular Formula: C₈H₈FNO₃
• Molecular Weight: 185.155
• Mol file: 1029598-42-2.mol

Synonyms:1-(4-fluorophenyl)-2-nitroethanol

Chemical Property of 1-(4-fluorophenyl)-2-nitroethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-fluorophenyl)-2-nitroethanol

There total 12 articles about 1-(4-fluorophenyl)-2-nitroethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

nitromethane (75-52-5) + 4-fluorobenzaldehyde (459-57-4) → 1-(4-fluorophenyl)-2-nitroethanol (1029598-42-2)

Guidance literature:

With C₂₈H₂₀Cu₂N₁₂O₄; In methanol; water; at 45 ℃; for 8h; diastereoselective reaction;

DOI:10.1002/cplu.201402200

Reference yield: 80.0%

1-(4-fluorophenyl)-2-nitroethan-1-one → 1-(4-fluorophenyl)-2-nitroethanol (1029598-42-2)

Guidance literature:

With formic acid; triethylamine; In N-methyl-acetamide;

Reference yield: 77.0%

4-fluorobenzaldehyde (459-57-4) + trimethylsilyl ester of aci-nitromethane (51146-35-1) → 1-(4-fluorophenyl)-2-nitroethanol (1029598-42-2)

Guidance literature:

With scandium tris(trifluoromethanesulfonate); In tetrahydrofuran; hexane; at -78 ℃; for 96h; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.12.056

upstream raw materials:

nitromethane

4-fluorobenzaldehyde

trimethylsilyl ester of aci-nitromethane

1-(p-fluorophenylcarbonyl)imidazole

Downstream raw materials:

2-amino-1-(4-fluorophenyl)ethanol

C₂₂H₃₆FNO₂

C₁₅H₁₃FN₄O₂S

C₁₅H₁₁FN₄O₂S