Trimethylsilyl ester of aci-nitromethane, also known as trimethylsilyl acetonitrile oxide or TMSNO, is a chemical compound with the molecular formula C4H9NOSi. It is a colorless liquid that is widely used as a protecting group in organic synthesis, particularly for the protection of carbonyl groups. TMSNO is formed by the reaction of acetonitrile with trimethylsilyl chloride (TMSCl) in the presence of a base, such as triethylamine (Et3N). The trimethylsilyl group (TMS) acts as a bulky, electron-donating group that shields the carbonyl oxygen, preventing unwanted side reactions. This protecting group can be selectively removed under mild conditions, such as treatment with tetrabutylammonium fluoride (TBAF) or hydrofluoric acid (HF), to regenerate the original carbonyl compound. TMSNO is a valuable reagent in the synthesis of various pharmaceuticals, agrochemicals, and other complex organic molecules due to its stability, selectivity, and ease of removal.
51146-35-1
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Basic information
- Product Name: trimethylsilyl ester of aci-nitromethane
- Synonyms: trimethylsilyl ester of aci-nitromethane
- CAS NO:51146-35-1
- Molecular Formula:
- Molecular Weight: 133.222
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: N/A
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: trimethylsilyl ester of aci-nitromethane(CAS DataBase Reference)
- NIST Chemistry Reference: trimethylsilyl ester of aci-nitromethane(51146-35-1)
- EPA Substance Registry System: trimethylsilyl ester of aci-nitromethane(51146-35-1)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 51146-35-1(Hazardous Substances Data)
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Check Digit Verification of cas no
The CAS Registry Mumber 51146-35-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,1,4 and 6 respectively; the second part has 2 digits, 3 and 5 respectively.Calculate Digit Verification of CAS Registry Number 51146-35:
(7*5)+(6*1)+(5*1)+(4*4)+(3*6)+(2*3)+(1*5)=91
91 % 10 = 1
So 51146-35-1 is a valid CAS Registry Number.
51146-35-1Upstream product
51146-35-1Downstream Products
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trimethylsilyl ester of aci-nitromethane
