2-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1H-benzo[d]imidazol-1-yl)-N-(4-methoxycarbonylphenyl)acetamide

Base Information

Chemical Name:2-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1H-benzo[d]imidazol-1-yl)-N-(4-methoxycarbonylphenyl)acetamide
CAS No.:695194-13-9
Molecular Formula:C₁₉H₁₆N₆O₄
Molecular Weight:392.374
Hs Code.:
Mol file:695194-13-9.mol

Synonyms:2-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1H-benzo[d]imidazol-1-yl)-N-(4-methoxycarbonylphenyl)acetamide

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Chemical Property of 2-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1H-benzo[d]imidazol-1-yl)-N-(4-methoxycarbonylphenyl)acetamide

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Technology Process of 2-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1H-benzo[d]imidazol-1-yl)-N-(4-methoxycarbonylphenyl)acetamide

There total 5 articles about 2-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1H-benzo[d]imidazol-1-yl)-N-(4-methoxycarbonylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 82525-64-2
chloro-N-(4-methoxycarbonylphenyl)acetamide

: 332026-86-5
3-amino-4-(1H-benzo[d]imidazol-2-yl)-1,2,5-oxadiazole

: 695194-13-9
2-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1H-benzo[d]imidazol-1-yl)-N-(4-methoxycarbonylphenyl)acetamide

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 7h;
DOI:10.1021/acs.jmedchem.1c00167

Reference yield:

: 619-45-4
4-methoxycarbonyl aniline

: 695194-13-9
2-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1H-benzo[d]imidazol-1-yl)-N-(4-methoxycarbonylphenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / chloroform / 0.25 h / 20 °C

1.2: 2 h / 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 7 h / 70 °C

With sodium hydrogencarbonate; caesium carbonate; In chloroform; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.1c00167

Reference yield:

: 63823-75-6
α-hydroxyimino-(1H-benzimidazol-2-yl) acetonitrile

: 695194-13-9
2-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1H-benzo[d]imidazol-1-yl)-N-(4-methoxycarbonylphenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; potassium hydroxide / water; diethylene glycol dimethyl ether / 6 h / 110 °C / Cooling with ice

2: caesium carbonate / N,N-dimethyl-formamide / 7 h / 70 °C

With hydroxylamine hydrochloride; caesium carbonate; potassium hydroxide; In diethylene glycol dimethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.1c00167