4-(2-Chloro-acetylamino)-benzoic acid methyl ester

Base Information

• Chemical Name: 4-(2-Chloro-acetylamino)-benzoic acid methyl ester
• CAS No.: 82525-64-2
• Molecular Formula: C10H10 Cl N O3
• Molecular Weight: 227.647
• Hs Code.: 2924299090
• Mol file: 82525-64-2.mol

Synonyms:Benzoicacid, 4-[(chloroacetyl)amino]-, methyl ester (9CI); Benzoic acid,p-2-chloroacetamido-, methyl ester (6CI); NSC 39579

Chemical Property of 4-(2-Chloro-acetylamino)-benzoic acid methyl ester

Chemical Property:

• Vapor Pressure: 4.89E-07mmHg at 25°C
• Boiling Point: 413.2°C at 760 mmHg
• Flash Point: 203.7°C
• PSA: 55.40000
• Density: 1.325g/cm³
• LogP: 1.72350

Purity/Quality:

99% ^*data from raw suppliers

Methyl4-[(Chloroacetyl)amino]benzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-Chloro-acetylamino)-benzoic acid methyl ester

There total 3 articles about 4-(2-Chloro-acetylamino)-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

chloroacetyl chloride (79-04-9) + 4-methoxycarbonyl aniline (619-45-4) → chloro-N-(4-methoxycarbonylphenyl)acetamide (82525-64-2)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 4h;

DOI:10.1021/acs.jmedchem.7b00587

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → chloro-N-(4-methoxycarbonylphenyl)acetamide (82525-64-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen chloride

2: benzene

With hydrogenchloride; benzene;

Reference yield:

→ chloro-N-(4-methoxycarbonylphenyl)acetamide (82525-64-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 6h;

upstream raw materials:

chloroacetyl chloride

4-methoxycarbonyl aniline

4-amino-benzoic acid

Downstream raw materials:

4-[(N-ethyl-glycyl)-amino]-benzoic acid methyl ester

C₂₇H₂₅N₃O₆S

C₂₇H₂₅N₃O₆S

N-(4-carbomethoxyphenyl)-2-[4-oxo-2-(4-methoxyphenyl)pyrimido[1,2-a]benzimidazol-10(4H)-yl]-acetamide

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