16-(3-Chlorophenoxy)-17,18,19,20-tetranor-2,3-trans-didehydro-pgf2-alpha

Base Information

Chemical Name:16-(3-Chlorophenoxy)-17,18,19,20-tetranor-2,3-trans-didehydro-pgf2-alpha
CAS No.:73275-75-9
Molecular Formula:C22H27ClO6
Molecular Weight:422.9
Hs Code.:

Synonyms:BRN 5640616;16-(3-Chlorophenoxy)-17,18,19,20-tetranor-2,3-trans-didehydro-pgf2-alpha;16-(3-Chlorophenoxy)-17,18,19,20-tetranor-2,3-trans-didehydroprostaglandin F2-alpha;2,5-Heptadienoic acid, 7-(2-(4-(3-chlorophenoxy)-3-hydroxy-1-butenyl)-3,5- dihydroxycyclopentyl)-, (1R-(1-alpha(2E,5Z),2-beta(1E,3R*),3-alpha,5-alpha))-;73275-75-9;C22H27ClO6;C22-H27-Cl-O6;LS-74200;J-519021;7-((R)-2-((R,E)-4-(3-Chlorophenoxy)-3-hydroxybut-1-en-1-yl)-3,5-dihydroxycyclopenta-2,4-dien-1-yl)heptanoic acid

Suppliers and Price of 16-(3-Chlorophenoxy)-17,18,19,20-tetranor-2,3-trans-didehydro-pgf2-alpha

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 16-(3-Chlorophenoxy)-17,18,19,20-tetranor-2,3-trans-didehydro-pgf2-alpha

Chemical Property:

Vapor Pressure:3.53E-17mmHg at 25°C
Boiling Point:638.5°C at 760 mmHg
Flash Point:340°C
PSA：107.22000
Density:1.341g/cm³
LogP:2.97100
XLogP3:2.8
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:10
Exact Mass:422.1496163
Heavy Atom Count:29
Complexity:590

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(C(C(C1O)C=CC(COC2=CC(=CC=C2)Cl)O)CC=CCC=CC(=O)O)O
Isomeric SMILES:C1C([C@@H](C(C1O)C/C=C/C/C=C\C(=O)O)/C=C/[C@H](COC2=CC(=CC=C2)Cl)O)O

Technology Process of 16-(3-Chlorophenoxy)-17,18,19,20-tetranor-2,3-trans-didehydro-pgf2-alpha

There total 13 articles about 16-(3-Chlorophenoxy)-17,18,19,20-tetranor-2,3-trans-didehydro-pgf2-alpha which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2E,5Z)-7-[(1R,2R,3R,5S)-2-[(E)-(R)-4-(3-Chloro-phenoxy)-3-(tetrahydro-pyran-2-yloxy)-but-1-enyl]-3,5-bis-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-hepta-2,5-dienoic acid

: 73275-75-9
16-(3-chlorophenoxy)-17,18,19,20-tetranor-2,3-trans-didehydroprostaglandin F_2α

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; at 45 ℃; for 1h; Yield given;
DOI:10.1021/jm00179a011

Reference yield:

: 40665-94-9
dimethyl 3-(3-chlorophenoxy)-2-oxopropylphosphonate

: 73275-75-9
16-(3-chlorophenoxy)-17,18,19,20-tetranor-2,3-trans-didehydroprostaglandin F_2α

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) NaH / 1.) THF, 25 deg C, 20 min, 2.) THF, from 25 deg C to 60 deg C, 4.5 h

2: NaBH₄ / methanol; tetrahydrofuran / -45 °C

3: K₂CO₃ / methanol / 1 h / 50 °C

4: p-toluenesulfonic acid / CH₂Cl₂ / 0.33 h / 25 °C

5: 1.) LDA / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, a) -78 deg C, 30 min, b) 20 deg C, 30 min

6: 75 percent / aq. KOH / methanol / 3 h / 50 °C

7: 30percent H₂O₂ / ethyl acetate; methanol / 0.33 h / 40 °C

8: 1 N aq. HCl / tetrahydrofuran / 1 h / 45 °C

With hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; dihydrogen peroxide; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm00179a011

Reference yield:

: 61218-06-2
methyl (Z)-7-[(1R,2R,3R,5S)-5-acetoxy-2-formyl-3-(2-tetrahydropyranyloxy)cyclopentyl]-5-heptenate

: 73275-75-9
16-(3-chlorophenoxy)-17,18,19,20-tetranor-2,3-trans-didehydroprostaglandin F_2α

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) NaH / 1.) THF, 25 deg C, 20 min, 2.) THF, from 25 deg C to 60 deg C, 4.5 h

2: NaBH₄ / methanol; tetrahydrofuran / -45 °C

3: K₂CO₃ / methanol / 1 h / 50 °C

4: p-toluenesulfonic acid / CH₂Cl₂ / 0.33 h / 25 °C

5: 1.) LDA / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, a) -78 deg C, 30 min, b) 20 deg C, 30 min

6: 75 percent / aq. KOH / methanol / 3 h / 50 °C

7: 30percent H₂O₂ / ethyl acetate; methanol / 0.33 h / 40 °C

8: 1 N aq. HCl / tetrahydrofuran / 1 h / 45 °C

With hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; dihydrogen peroxide; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm00179a011