40665-94-9

Basic information

• Product Name: Dimethyl 3-(3-chlorophenoxy)-2-oxopropylphosphonate
• Synonyms: DIMETHYL 3-(3-CHLOROPHENOXY)-2-OXOPROPYLPHOSPHONATE;Dimethyl 3-(3-chlorophenoxy)-2-oxopropylphosphonate, 98 %;3-(m-Chlorophenoxy)-2-oxopropylphosphonic acid dimethyl ester;[2-Oxo-3-(3-chloro-phenoxy)-propyl]-phosphonic;Phosphonic acid, P-[3-(3-chlorophenoxy)-2-oxopropyl]-,dimethyl ester
• CAS NO: 40665-94-9
• Molecular Formula: C₁₁H₁₄ClO₅P
• Molecular Weight: 292.65
• Mol File: 40665-94-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 400.1 °C at 760 mmHg
• Flash Point: 303.5 °C
• Appearance: /
• Density: 1.298 g/cm³
• Vapor Pressure: 1.31E-06mmHg at 25°C
• Refractive Index: 1.504
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Dimethyl 3-(3-chlorophenoxy)-2-oxopropylphosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: Dimethyl 3-(3-chlorophenoxy)-2-oxopropylphosphonate(40665-94-9)
• EPA Substance Registry System: Dimethyl 3-(3-chlorophenoxy)-2-oxopropylphosphonate(40665-94-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 40665-94-9(Hazardous Substances Data)

Usage

Uses

Dimethyl 3-(3-Chlorophenoxy)-2-oxopropylphosphonate is an intermediate used in the synthesis of (+)-cloprostenol and α-pentanorbenzo analogs of prostaglandins.

InChI:InChI=1/C11H14ClO5P/c1-15-18(14,16-2)8-10(13)7-17-11-5-3-4-9(12)6-11/h3-6H,7-8H2,1-2H3

Upstream product

• 108-43-0 3-monochlorophenol 
• 52094-98-1 ethyl (3-chlorophenoxy)acetate 
• 756-79-6 dimethyl methane phosphonate 
• 63501-50-8 dimethyl 3-(3-chlorophenoxy)-2-semicarbazonopropylphosphonate 
• 74411-14-6 methyl 2-(3-chlorophenoxy)acetate 

Downstream Products

• 62561-53-9 16-(3-chlorophenoxy)-17,18,19,20-tetranorprostaglandin F_2α methyl ester 9,11,15-tris(tetrahydropyran-2-yl ether) 
• 62524-98-5 16-(3-chlorophenoxy)-17,18,19,20-tetranor-2,3-trans-didehydroprostaglandin F_2α methyl ester 9,11,15-tris(tetrahydropyran-2-yl ether) 
• 62559-75-5 16-(3-chlorophenoxy)-17,18,19,20-tetranor-2-(phenylselenyl)prostaglandin F_2α methyl ester 9,11,15-tris(tetrahydropyran-2-yl ether) 
• 64775-52-6 16-(3-chlorophenoxy)-17,18,19,20-tetranor-3,4-cis-didehydroprostaglandin F_2α methyl ester 
• 62524-97-4 (Z)-7-[(1R,2R,3R,5S)-5-Acetoxy-2-[(E)-(S)-4-(3-chloro-phenoxy)-3-hydroxy-but-1-enyl]-3-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-hept-5-enoic acid methyl ester 
• 62561-54-0 16-(4-chlorophenoxy)-17,18,19,20-tetranorprostaglandin F_2α 9-acetate methyl ester 11-(tetrahydropyran-2-yl ether) 
• 192992-24-8 Isopropyl [2R(1E),3R(4Z),4R]-7-[Tetrahydro-2-[4-(3-chlorophenoxy)-3-oxo-1-butenyl]-4-(tetrahydropyran-2-yl)oxy-3-furanyl]-4-heptenoate 
• 54276-21-0 (+)-cloprostenol 
• 54294-93-8 Biphenyl-4-carboxylic acid (3aR,4R,5R,6aS)-4-[(E)-(S)-4-(3-chloro-phenoxy)-3-hydroxy-but-1-enyl]-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester 
• 54713-44-9 (3aR,4R,5R,6aS)-4-((R,E)-4-(3-chlorophenoxy)-3-hydroxybut-1-enyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl[1,1′-biphenyl]-4-carboxylate 
• 70783-89-0 (R)-11-(3-chlorophenoxy)-2-hydroxy-2,6-dimethylundec-8-trans-en-10-one 

Relevant articles and documents

The optically pure sodium alcoholate dextrorotary chlorine forefront of the method for the preparation of

The invention relates to a preparation method of optically pure dextro cloprostenol sodium. The method comprises the following steps: using the combination of ketonic acid and S-phenylethylamine resolving agent, and carrying out chiral resolution to obtain S-propenylphosphonate with the structural formula of R-ketonic acid; then separating to obtain R-chlorone and preparing to obtain R-cloprostenol sodium. The preparation method has the benefits that the optically pure dextro cloprostenol sodium in the invention is called D-cloprostenol sodium for short, the using amount only needs one third of cloprostenol sodium being a racemic modification in current market, and the pesticide effect is obviously better than cloprostenol sodium with three times of using amount.

Preparation of cloprostenol and fluprostenol analogs for treating glaucoma and ocular hypertension.

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PROSTANOIDS. XXX. SYNTHESIS OF THE ANALOGS OF 11-DEOXYPROSTA-GLANDINS E AND F

A practical approach to 11-deoxyprostaglandins is developed on the basis of the chemo- and stereoselective reduction of the readily obtainable methyl 9,15-diketo-16-aryloxyprostenoates.