2-{2-[2-benzyloxymethyl-3-(3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yloxy]-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy}-3-cyclohexyl-propionic acid benzyl ester

Base Information

Chemical Name:2-{2-[2-benzyloxymethyl-3-(3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yloxy]-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy}-3-cyclohexyl-propionic acid benzyl ester
CAS No.:252896-26-7
Molecular Formula:C₆₂H₇₆O₁₅
Molecular Weight:1061.28
Hs Code.:

2-{2-[2-benzyloxymethyl-3-(3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yloxy]-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy}-3-cyclohexyl-propionic acid benzyl ester

Synonyms:2-{2-[2-benzyloxymethyl-3-(3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yloxy]-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy}-3-cyclohexyl-propionic acid benzyl ester

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Chemical Property of 2-{2-[2-benzyloxymethyl-3-(3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yloxy]-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy}-3-cyclohexyl-propionic acid benzyl ester

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Technology Process of 2-{2-[2-benzyloxymethyl-3-(3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yloxy]-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy}-3-cyclohexyl-propionic acid benzyl ester

There total 11 articles about 2-{2-[2-benzyloxymethyl-3-(3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yloxy]-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy}-3-cyclohexyl-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 187404-16-6
benzyl (R)-3-cyclohexyl-2-trifluoromethanesulfonyloxy-propionate

: 252896-25-6
(2R,3R,4S,5R,6R)-2-[(2R,3S,4R)-2-Benzyloxymethyl-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yloxy]-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol

: 252896-26-7
2-{2-[2-benzyloxymethyl-3-(3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yloxy]-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy}-3-cyclohexyl-propionic acid benzyl ester

Guidance literature:: (2R,3R,4S,5R,6R)-2-[(2R,3S,4R)-2-Benzyloxymethyl-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yloxy]-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol; With di(n-butyl)tin oxide; In methanol; for 2h; Heating;

benzyl (R)-3-cyclohexyl-2-trifluoromethanesulfonyloxy-propionate; With cesium fluoride; In 1,2-dimethoxyethane; at 20 ℃; for 8h;
DOI:10.1021/jm990422n

Reference yield:

: 828-01-3,7326-19-4,20312-36-1,156-05-8
D-phenyllactic acid

: 252896-26-7
2-{2-[2-benzyloxymethyl-3-(3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yloxy]-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy}-3-cyclohexyl-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: H₂ / 5 percent Rh/Al₂O₃ / tetrahydrofuran; H₂O / 6 h / 20 °C

2.1: aq. Cs₂CO₃ / methanol / pH 8.1

2.2: dimethylformamide / 16 h / 20 °C

3.1: 2,6-di-tert-butyl pyridine / CH₂Cl₂ / 4 h / -20 °C

4.1: Bu₂SnO / methanol / 2 h / Heating

4.2: 68 percent / CsF / 1,2-dimethoxy-ethane / 8 h / 20 °C

With 2,6-di-tert-butyl-pyridine; hydrogen; di(n-butyl)tin oxide; caesium carbonate; Rh/Al₂O₃; In tetrahydrofuran; methanol; dichloromethane; water; 1.1: Hydrogenation / 2.1: Metallation / 2.2: Condensation / 3.1: Condensation / 4.1: activation / 4.2: Condensation;
DOI:10.1021/jm990422n

Reference yield:

: 135214-83-4
1,5-Anhydro-2-deoxy-4,6-O-(phenylmethylene)-D-arabino-hexopyranoside

: 252896-26-7
2-{2-[2-benzyloxymethyl-3-(3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yloxy]-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy}-3-cyclohexyl-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 72 percent / NIS; trifluoromethanesulfonic acid / CH₂Cl₂ / 0 °C

2.1: 72 percent / NaCNBH₃; HCl / diethyl ether; tetrahydrofuran

3.1: Et₄NBr / dimethylformamide; CH₂Cl₂ / 44 h / 20 °C

4.1: 98 percent / NaOMe / methanol / 3 h / 20 °C

5.1: Bu₂SnO / methanol / 2 h / Heating

5.2: 68 percent / CsF / 1,2-dimethoxy-ethane / 8 h / 20 °C

With hydrogenchloride; N-iodo-succinimide; trifluorormethanesulfonic acid; tetraethylammonium bromide; sodium methylate; di(n-butyl)tin oxide; sodium cyanoborohydride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 1.1: Condensation / 2.1: reductive ring opening / 3.1: Condensation / 4.1: Deacetylation / 5.1: activation / 5.2: Condensation;
DOI:10.1021/jm990422n