benzyl (R)-3-cyclohexyl-2-trifluoromethanesulfonyloxy-propionate

Base Information

Chemical Name:benzyl (R)-3-cyclohexyl-2-trifluoromethanesulfonyloxy-propionate
CAS No.:187404-16-6
Molecular Formula:C₁₇H₂₁F₃O₅S
Molecular Weight:394.412
Hs Code.:

Synonyms:benzyl (R)-3-cyclohexyl-2-trifluoromethanesulfonyloxy-propionate

Suppliers and Price of benzyl (R)-3-cyclohexyl-2-trifluoromethanesulfonyloxy-propionate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of benzyl (R)-3-cyclohexyl-2-trifluoromethanesulfonyloxy-propionate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of benzyl (R)-3-cyclohexyl-2-trifluoromethanesulfonyloxy-propionate

There total 13 articles about benzyl (R)-3-cyclohexyl-2-trifluoromethanesulfonyloxy-propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 161313-45-7
(2R)-2-hydroxy-3-cyclohexyl-propionic acid benzyl ester

: 187404-16-6
benzyl (R)-3-cyclohexyl-2-trifluoromethanesulfonyloxy-propionate

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; Inert atmosphere;
DOI:10.1002/cmdc.202100514

Reference yield:

: 50353-47-4
phenyl acetaldehyde cyanohydrin

: 187404-16-6
benzyl (R)-3-cyclohexyl-2-trifluoromethanesulfonyloxy-propionate

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; hydrogenchloride / 1 h / 95 °C

2.1: (2S)-2-phenylglycinol / iso-butanol / 80 - 115 °C / Resolution of racemate

2.2: Resolution of racemate

3.1: 5% rhodium-on-charcoal; hydrogen / ethanol / 3 h / 50 °C / 11251.1 Torr

4.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetone / 40 °C

5.1: dichloromethane

With hydrogenchloride; 5% rhodium-on-charcoal; (2S)-2-phenylglycinol; water; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; In ethanol; dichloromethane; acetone; iso-butanol;
DOI:10.1021/op030202q

Reference yield:

: 828-01-3,7326-19-4,20312-36-1,156-05-8
D-phenyllactic acid

: 187404-16-6
benzyl (R)-3-cyclohexyl-2-trifluoromethanesulfonyloxy-propionate

Guidance literature:: Multi-step reaction with 3 steps

1.1: H₂ / 5 percent Rh/Al₂O₃ / tetrahydrofuran; H₂O / 6 h / 20 °C

2.1: aq. Cs₂CO₃ / methanol / pH 8.1

2.2: dimethylformamide / 16 h / 20 °C

3.1: 2,6-di-tert-butyl pyridine / CH₂Cl₂ / 4 h / -20 °C

With 2,6-di-tert-butyl-pyridine; hydrogen; caesium carbonate; Rh/Al₂O₃; In tetrahydrofuran; methanol; dichloromethane; water; 1.1: Hydrogenation / 2.1: Metallation / 2.2: Condensation / 3.1: Condensation;
DOI:10.1021/jm990422n