(R)-N-(6-phenylpyrimidin-4-yl)-4H-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octan]-2-amine

Base Information

Chemical Name:(R)-N-(6-phenylpyrimidin-4-yl)-4H-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octan]-2-amine
CAS No.:1192807-65-0
Molecular Formula:C₁₉H₂₁N₅O
Molecular Weight:335.409
Hs Code.:

Synonyms:(R)-N-(6-phenylpyrimidin-4-yl)-4H-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octan]-2-amine

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Chemical Property of (R)-N-(6-phenylpyrimidin-4-yl)-4H-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octan]-2-amine

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Technology Process of (R)-N-(6-phenylpyrimidin-4-yl)-4H-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octan]-2-amine

There total 7 articles about (R)-N-(6-phenylpyrimidin-4-yl)-4H-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octan]-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: (S)-3-(aminomethyl)quinuclidin-3-ol dihydrochloride salt

: dimethyl (6-phenylpyrimidin-4-yl)carbonimidodithioate

: 1192807-65-0
(R)-N-(6-phenylpyrimidin-4-yl)-4H-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octan]-2-amine

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 3h;
DOI:10.1021/acsmedchemlett.7b00032

Reference yield:

: 3435-29-8
4-Amino-6-phenylpyrimidine

: 1192807-65-0
(R)-N-(6-phenylpyrimidin-4-yl)-4H-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octan]-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / N,N-dimethyl-formamide / 0.25 h

1.2: 0.25 h

2.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

With caesium carbonate; sodium hydroxide; In N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.7b00032

Reference yield:

: 98-80-6
phenylboronic acid

: 1192807-65-0
(R)-N-(6-phenylpyrimidin-4-yl)-4H-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octan]-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; ethanol; 1,4-dioxane / 2 h / 125 °C

2.1: sodium hydroxide / N,N-dimethyl-formamide / 0.25 h

2.2: 0.25 h

3.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; caesium carbonate; sodium hydroxide; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.7b00032