4-((2-(4-(3′-methoxy[1,1′-biphenyl]-4-yl)piperazin-1-yl)ethyl)(propyl)amino)cyclohexanone

Base Information

Chemical Name:4-((2-(4-(3′-methoxy[1,1′-biphenyl]-4-yl)piperazin-1-yl)ethyl)(propyl)amino)cyclohexanone
CAS No.:1563175-16-5
Molecular Formula:C₂₈H₃₉N₃O₂
Molecular Weight:449.637
Hs Code.:

Synonyms:4-((2-(4-(3′-methoxy[1,1′-biphenyl]-4-yl)piperazin-1-yl)ethyl)(propyl)amino)cyclohexanone

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Chemical Property of 4-((2-(4-(3′-methoxy[1,1′-biphenyl]-4-yl)piperazin-1-yl)ethyl)(propyl)amino)cyclohexanone

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Technology Process of 4-((2-(4-(3′-methoxy[1,1′-biphenyl]-4-yl)piperazin-1-yl)ethyl)(propyl)amino)cyclohexanone

There total 9 articles about 4-((2-(4-(3′-methoxy[1,1′-biphenyl]-4-yl)piperazin-1-yl)ethyl)(propyl)amino)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1563175-09-6
N-(2-(4-(3′-methoxy-[1,1′-biphenyl]-4-yl)piperazin-1-yl)ethyl)-N-propyl-1,4-dioxaspiro[4.50]decan-8-amine

: 1563175-16-5
4-((2-(4-(3′-methoxy[1,1′-biphenyl]-4-yl)piperazin-1-yl)ethyl)(propyl)amino)cyclohexanone

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; at 80 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm401883v

Reference yield:

: 1225962-32-2
1-(3′-methoxy-biphenyl-4-yl)piperazine

: 1563175-16-5
4-((2-(4-(3′-methoxy[1,1′-biphenyl]-4-yl)piperazin-1-yl)ethyl)(propyl)amino)cyclohexanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetonitrile / 14 h / Inert atmosphere; Reflux

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 20 °C / Inert atmosphere

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

3.2: 1.33 h / 20 °C / Inert atmosphere

4.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 48 h / 20 °C / Inert atmosphere

5.1: hydrogenchloride / tetrahydrofuran / 2 h / 80 °C / Inert atmosphere

With hydrogenchloride; oxalyl dichloride; tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; acetonitrile; 3.1: |Swern Oxidation / 3.2: |Swern Oxidation;
DOI:10.1021/jm401883v

Reference yield:

: 1563175-20-1
1-(2-(t-butyldimethylsilyloxy)ethyl)-4-(3′-methoxybiphenyl-4-yl)piperazine

: 1563175-16-5
4-((2-(4-(3′-methoxy[1,1′-biphenyl]-4-yl)piperazin-1-yl)ethyl)(propyl)amino)cyclohexanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 20 °C / Inert atmosphere

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

2.2: 1.33 h / 20 °C / Inert atmosphere

3.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 48 h / 20 °C / Inert atmosphere

4.1: hydrogenchloride / tetrahydrofuran / 2 h / 80 °C / Inert atmosphere

With hydrogenchloride; oxalyl dichloride; tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; acetic acid; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; 2.1: |Swern Oxidation / 2.2: |Swern Oxidation;
DOI:10.1021/jm401883v