N-(2-(4-(3′-methoxy-[1,1′-biphenyl]-4-yl)piperazin-1-yl)ethyl)-N-propyl-1,4-dioxaspiro[4.50]decan-8-amine

Base Information

Chemical Name:N-(2-(4-(3′-methoxy-[1,1′-biphenyl]-4-yl)piperazin-1-yl)ethyl)-N-propyl-1,4-dioxaspiro[4.50]decan-8-amine
CAS No.:1563175-09-6
Molecular Formula:C₃₀H₄₃N₃O₃
Molecular Weight:493.69
Hs Code.:

Synonyms:N-(2-(4-(3′-methoxy-[1,1′-biphenyl]-4-yl)piperazin-1-yl)ethyl)-N-propyl-1,4-dioxaspiro[4.50]decan-8-amine

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Chemical Property of N-(2-(4-(3′-methoxy-[1,1′-biphenyl]-4-yl)piperazin-1-yl)ethyl)-N-propyl-1,4-dioxaspiro[4.50]decan-8-amine

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Technology Process of N-(2-(4-(3′-methoxy-[1,1′-biphenyl]-4-yl)piperazin-1-yl)ethyl)-N-propyl-1,4-dioxaspiro[4.50]decan-8-amine

There total 8 articles about N-(2-(4-(3′-methoxy-[1,1′-biphenyl]-4-yl)piperazin-1-yl)ethyl)-N-propyl-1,4-dioxaspiro[4.50]decan-8-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1563175-30-3
2-(4-(3′-methoxybiphenyl-4-yl)piperazin-1-yl)acetaldehyde

: 676124-70-2
4-propylaminocyclohexan-1-one ethylene acetal

: 1563175-09-6
N-(2-(4-(3′-methoxy-[1,1′-biphenyl]-4-yl)piperazin-1-yl)ethyl)-N-propyl-1,4-dioxaspiro[4.50]decan-8-amine

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1021/jm401883v

Reference yield:

: 1225962-32-2
1-(3′-methoxy-biphenyl-4-yl)piperazine

: 1563175-09-6
N-(2-(4-(3′-methoxy-[1,1′-biphenyl]-4-yl)piperazin-1-yl)ethyl)-N-propyl-1,4-dioxaspiro[4.50]decan-8-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetonitrile / 14 h / Inert atmosphere; Reflux

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 20 °C / Inert atmosphere

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

3.2: 1.33 h / 20 °C / Inert atmosphere

4.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 48 h / 20 °C / Inert atmosphere

With oxalyl dichloride; tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; acetonitrile; 3.1: |Swern Oxidation / 3.2: |Swern Oxidation;
DOI:10.1021/jm401883v

Reference yield:

: 1563175-20-1
1-(2-(t-butyldimethylsilyloxy)ethyl)-4-(3′-methoxybiphenyl-4-yl)piperazine

: 1563175-09-6
N-(2-(4-(3′-methoxy-[1,1′-biphenyl]-4-yl)piperazin-1-yl)ethyl)-N-propyl-1,4-dioxaspiro[4.50]decan-8-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 20 °C / Inert atmosphere

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

2.2: 1.33 h / 20 °C / Inert atmosphere

3.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 48 h / 20 °C / Inert atmosphere

With oxalyl dichloride; tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; acetic acid; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; 2.1: |Swern Oxidation / 2.2: |Swern Oxidation;
DOI:10.1021/jm401883v