potassium N-acetyl-D-leucine salt

Base Information

• Chemical Name: potassium N-acetyl-D-leucine salt
• CAS No.: 909122-82-3
• Molecular Formula: C₈H₁₄NO₃*K
• Molecular Weight: 211.302
• Mol file: 909122-82-3.mol

Synonyms:potassium N-acetyl-D-leucine salt

Chemical Property of potassium N-acetyl-D-leucine salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of potassium N-acetyl-D-leucine salt

There total 3 articles about potassium N-acetyl-D-leucine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-(R)-1-(2,3-dihydrobenzofuran-5-yl)-2,3,4,9-tetrahydro-1H-β-carboline N-acetyl-D-leucine salt (865087-85-0) + benzyl bromide (100-39-0) → potassium N-acetyl-D-leucine salt (909122-82-3) + 1-(R)-1-(2,3-dihydrobenzofuran-5-yl)-2-benzyl-2,3,4,9-tetrahydro-1H-β-carboline (374926-58-6)

Guidance literature:

With potassium carbonate; In dichloromethane; at 20 - 40 ℃; for 11h;

Reference yield: 94.0%

1-(R)-1-(2,3-dihydrobenzofuran-5-yl)-2,3,4,9-tetrahydro-1H-β-carboline N-acetyl-D-leucine salt (865087-85-0) → potassium N-acetyl-D-leucine salt (909122-82-3) + 1-(R)-1-(2,3-dihydrobenzofuran-5-yl)-2-benzyl-2,3,4,9-tetrahydro-1H-β-carboline (374926-58-6)

Guidance literature:

1-(R)-1-(2,3-dihydrobenzofuran-5-yl)-2,3,4,9-tetrahydro-1H-β-carboline N-acetyl-D-leucine salt; With potassium carbonate; In dichloromethane; at 20 ℃; for 0.216667h; Inert atmosphere; Large scale;

With benzyl bromide; In dichloromethane; at 20 - 38 ℃; for 11h; Inert atmosphere; Large scale;

DOI:10.1021/op050079y

Reference yield:

N-acetyl-D-leucine (19764-30-8) + 1-(2,3-dihydro-5-benzofuranyl)-2,3,4,9-tetrahydro-1H-β-carboline (199678-69-8) → potassium N-acetyl-D-leucine salt (909122-82-3) + 1-(R)-1-(2,3-dihydrobenzofuran-5-yl)-2-benzyl-2,3,4,9-tetrahydro-1H-β-carboline (374926-58-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methanol; ethyl acetate / 20 - 65 °C / Inert atmosphere

2.1: potassium carbonate / dichloromethane / 0.22 h / 20 °C / Inert atmosphere; Large scale

2.2: 11 h / 20 - 38 °C / Inert atmosphere; Large scale

With potassium carbonate; In methanol; dichloromethane; ethyl acetate;

DOI:10.1021/op050079y

upstream raw materials:

1-(R)-1-(2,3-dihydrobenzofuran-5-yl)-2,3,4,9-tetrahydro-1H-β-carboline N-acetyl-D-leucine salt

benzyl bromide

N-acetyl-D-leucine

1-(2,3-dihydro-5-benzofuranyl)-2,3,4,9-tetrahydro-1H-β-carboline

Refernces

• 1、 -. "AN EFFICIENT AND STEREOSELECTIVE PROCESS FOR LARGE SCALE SYNTHESIS OF 3-(R)-3- (2,3-DIHYDROBENZOFURAN-5-YL)-1,2,3,4- TETRAHYDROPYRROLO{3,4-B}QUINOLIN-9-ONE". Page/Page column 15; 28; 29. . Retrieved 2008/06/13.