4-[5-(3,5-dichloro-phenyl)-2-oxo-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-benzoic acid methyl ester

Base Information

Chemical Name:4-[5-(3,5-dichloro-phenyl)-2-oxo-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-benzoic acid methyl ester
CAS No.:1331886-87-3
Molecular Formula:C₂₀H₁₃Cl₂F₃O₄
Molecular Weight:445.222
Hs Code.:

Synonyms:4-[5-(3,5-dichloro-phenyl)-2-oxo-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-benzoic acid methyl ester

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Chemical Property of 4-[5-(3,5-dichloro-phenyl)-2-oxo-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-benzoic acid methyl ester

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Technology Process of 4-[5-(3,5-dichloro-phenyl)-2-oxo-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-benzoic acid methyl ester

There total 5 articles about 4-[5-(3,5-dichloro-phenyl)-2-oxo-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1331886-85-1
4-(3,5-dichloro-phenyl)-5,5,5-trifluoro-4-hydroxy-pent-2-ynoic acid methyl ester

: 103440-53-5
4-iodo-2-methyl-benzoic acid methyl ester

: 1331886-87-3
4-[5-(3,5-dichloro-phenyl)-2-oxo-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-benzoic acid methyl ester

Guidance literature:: 4-(3,5-dichloro-phenyl)-5,5,5-trifluoro-4-hydroxy-pent-2-ynoic acid methyl ester; 4-iodo-2-methyl-benzoic acid methyl ester; With tributyl-amine; palladium diacetate; tris-(o-tolyl)phosphine; In N,N-dimethyl-formamide; for 0.5h; Inert atmosphere;

With formic acid; In N,N-dimethyl-formamide; at 70 ℃; for 1h; Inert atmosphere;

Reference yield:

: 130336-16-2
3,5-dichloro-2,2,2-trifluoroacetophenone

: 1331886-87-3
4-[5-(3,5-dichloro-phenyl)-2-oxo-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethyl bromide; magnesium / tetrahydrofuran / 0.67 h / 0 - 20 °C

1.2: 0 °C

2.1: tetrabutyl ammonium fluoride / ethyl acetate; tetrahydrofuran / 22 h / Inert atmosphere

3.1: Jones reagent / acetone / 5.5 h / 0 °C / Inert atmosphere

4.1: toluene; hexane; methanol / 4 h / 0 °C

5.1: palladium diacetate; tris-(o-tolyl)phosphine; tributyl-amine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

5.2: 1 h / 70 °C / Inert atmosphere

With Jones reagent; ethyl bromide; tributyl-amine; tetrabutyl ammonium fluoride; palladium diacetate; magnesium; tris-(o-tolyl)phosphine; In tetrahydrofuran; methanol; hexane; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 1331887-02-5
C₁₄H₁₅Cl₂F₃O₂Si

: 1331886-87-3
4-[5-(3,5-dichloro-phenyl)-2-oxo-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrabutyl ammonium fluoride / ethyl acetate; tetrahydrofuran / 22 h / Inert atmosphere

2.1: Jones reagent / acetone / 5.5 h / 0 °C / Inert atmosphere

3.1: toluene; hexane; methanol / 4 h / 0 °C

4.1: palladium diacetate; tris-(o-tolyl)phosphine; tributyl-amine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

4.2: 1 h / 70 °C / Inert atmosphere

With Jones reagent; tributyl-amine; tetrabutyl ammonium fluoride; palladium diacetate; tris-(o-tolyl)phosphine; In tetrahydrofuran; methanol; hexane; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene;