Technology Process of 4-[5-(3,5-dichloro-phenyl)-2-oxo-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-benzoic acid methyl ester
There total 5 articles about 4-[5-(3,5-dichloro-phenyl)-2-oxo-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-benzoic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(3,5-dichloro-phenyl)-5,5,5-trifluoro-4-hydroxy-pent-2-ynoic acid methyl ester; 4-iodo-2-methyl-benzoic acid methyl ester;
With
tributyl-amine; palladium diacetate; tris-(o-tolyl)phosphine;
In
N,N-dimethyl-formamide;
for 0.5h;
Inert atmosphere;
With
formic acid;
In
N,N-dimethyl-formamide;
at 70 ℃;
for 1h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: ethyl bromide; magnesium / tetrahydrofuran / 0.67 h / 0 - 20 °C
1.2: 0 °C
2.1: tetrabutyl ammonium fluoride / ethyl acetate; tetrahydrofuran / 22 h / Inert atmosphere
3.1: Jones reagent / acetone / 5.5 h / 0 °C / Inert atmosphere
4.1: toluene; hexane; methanol / 4 h / 0 °C
5.1: palladium diacetate; tris-(o-tolyl)phosphine; tributyl-amine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere
5.2: 1 h / 70 °C / Inert atmosphere
With
Jones reagent; ethyl bromide; tributyl-amine; tetrabutyl ammonium fluoride; palladium diacetate; magnesium; tris-(o-tolyl)phosphine;
In
tetrahydrofuran; methanol; hexane; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrabutyl ammonium fluoride / ethyl acetate; tetrahydrofuran / 22 h / Inert atmosphere
2.1: Jones reagent / acetone / 5.5 h / 0 °C / Inert atmosphere
3.1: toluene; hexane; methanol / 4 h / 0 °C
4.1: palladium diacetate; tris-(o-tolyl)phosphine; tributyl-amine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere
4.2: 1 h / 70 °C / Inert atmosphere
With
Jones reagent; tributyl-amine; tetrabutyl ammonium fluoride; palladium diacetate; tris-(o-tolyl)phosphine;
In
tetrahydrofuran; methanol; hexane; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene;
