130336-16-2Relevant articles and documents
PROCESS FOR THE PREPARATION OF 3,5-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE
-
Page/Page column 8-9, (2021/12/08)
The present invention relates to an improved process for the preparation of 3,5-Dichloro-2,2,2-Trifluoroacetophenone of formula (I). The present invention further provides an improved process for the preparation of Fluralaner using 3,5-dichloro-2,2,2-trifluoroacetophenone of formula (I) obtained by a process described herein.
Preparation method of trifluoroacetophenone derivative
-
Paragraph 0037; 0040-0041; 0046; 0048; 0052; 0066-0075; 0079, (2021/10/05)
The invention relates to the field of organic synthesis, in particular to a preparation method of a trifluoroacetophenone derivative. Substituted aniline is used as a raw material, and preparation of the trifluoroacetophenone derivative is completed through three steps including diazotization reaction, coupling reaction and hydrolysis reaction. The preparation method has the advantages of simple process, high yield and less three wastes generated by the whole reaction, and is suitable for large-scale industrial production.
Preparation method of 3,5-dihalo trifluoroacetophenone and derivative thereof
-
Paragraph 0024; 0026, (2020/12/31)
The invention relates to the technical field of chemical pharmacy, particularly to a preparation method of 3,5-dihalo trifluoroacetophenone and a derivative thereof. According to the invention, , thederivatives of 3,5-dihalo trifluoroacetophenone is prepared by using 3-halogen-4-nitro trifluoroacetophenone as a raw material through reduction reaction, halogenation reaction and amino substitutionreaction, wherein the raw materials are cheap and easy to obtain, the process is simple, and the method is mild in condition, has a large-scale production prospect and has a relatively good economic effect.