130336-16-2

Usage

Uses

3'',5''-Dichloro-2,2,2-trifluoroacetophenone is a reagent used for enantioselective preparation of benzazephinoindoles bearing trifluoromethylated quaternary stereocenters catalyzed by chiral spirocyclic phosphoric acids

InChI:InChI=1/C8H3Cl2F3O/c9-5-1-4(2-6(10)3-5)7(14)8(11,12)13/h1-3H

Upstream product

• 19752-55-7 1-bromo-3,5-dichlorobenzene 
• 407-25-0 trifluoroacetic anhydride 
• 340-07-8 N-(trifluoroacetyl)piperidine 
• 108-70-3 1,3,5-trichlorobenzene 
• 360-92-9 N,N-diethyl-2,2,2-trifluoroacetamide 
• 1547-87-1 N,N-dimethyl-2,2,2-trifluoroacetamide 
• 360-95-2 2,2,2-Trifluoro-1-morpholin-4-yl-ethanone 
• 60884-90-4 calcium bistrifluoroacetate 
• 2923-18-4 sodium 2,2,2-trifluoroacetate 
• 354-31-4 trifluoroacetyl bromide 
• 354-32-5 trifluoracetyl chloride 
• 431-47-0 trifluoroacetic acid-methyl ester 
• 10203-08-4 3,5-dichlorobenzaldehyde 
• 81290-20-2 (trifluoromethyl)trimethylsilane 

Downstream Products

• 943436-51-9 1-(4-bromo-3-methylphenyl)-3-(3,5-dichlorophenyl)-3-hydroxy-4,4,4-trifluorobutane-1-one 
• 943436-54-2 (Z)-1-(4-bromophenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-2-butene-1-one 
• 1095275-39-0 Methyl 4-(3-(3,5-dichlorophenyl)-4,4,4-trifluoro-2-butenoyl) benzoate 
• 864725-22-4 1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene 
• 1446516-76-2 (E)-1-(3-bromo-1,1,1-trifluorobut-2-en-2-yl)-3,5-dichlorobenzene 
• 1446516-82-0 1,3-dichloro-5-(3,4-dibromo-1,1,1-trifluorobut-2-en-2-yl)benzene 
• 1446516-86-4 1,3-dichloro-5-(3,4-dibromo-1,1,1-trifluorobut-2-en-2-yl)benzene 
• 1446516-75-1 1,3-dichloro-5-(1,1-dibromo-3,3,3-trifluoroprop-1-en-2-yl)benzene 
• 1556019-41-0 N-[(1S)-1-[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]phenyl]ethyl]acetamide 
• 1449217-46-2 3-{4-[(Z)-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-but-2-enoyl]-phenyl}-3-fluoro-azetidine-1-carboxylic acid tert-butyl ester 
• 1429624-43-0 (E)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-1-(1H-pyrrol-1-yl)but-2-en-1-one 

Relevant academic research and scientific papers

Preparation method of 3, 5-substituted-4-amino trifluoroacetophenone and derivatives thereof

The invention relates to the field of organic pharmaceutical synthesis, in particular to a preparation method of 3, 5-substituted-4-amino trifluoroacetophenone and derivatives thereof, and the preparation method of the 3, 5-substituted-4-amino trifluoroacetophenone comprises the following steps: by taking ortho-disubstituted p-aniline as a raw material, carrying out amino protection, acylation reaction and amino deprotection to obtain 4-amino trifluoroacetophenone. The reaction raw materials are simple and easy to obtain, the yield is relatively high, the reaction conditions are mild, and the method has a relatively good industrial application prospect. Besides, on the basis of the reaction, the 3, 5-substituted-4-amino trifluoroacetophenone is further subjected to amino diazotization to prepare the derivative of the 3, 5-substituted-4-amino trifluoroacetophenone, and the derivative has a relatively great application prospect in industry.

Preparation method of trifluoroacetophenone derivative

The invention relates to the field of organic synthesis, in particular to a preparation method of a trifluoroacetophenone derivative. Substituted aniline is used as a raw material, and preparation of the trifluoroacetophenone derivative is completed through three steps including diazotization reaction, coupling reaction and hydrolysis reaction. The preparation method has the advantages of simple process, high yield and less three wastes generated by the whole reaction, and is suitable for large-scale industrial production.

PROCESS FOR THE PREPARATION OF 3,5-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE

The present invention relates to an improved process for the preparation of 3,5-Dichloro-2,2,2-Trifluoroacetophenone of formula (I). The present invention further provides an improved process for the preparation of Fluralaner using 3,5-dichloro-2,2,2-trifluoroacetophenone of formula (I) obtained by a process described herein.

Synthesis method of 3', 5'-dichloro-2, 2, 2-trifluoroacetophenone

The invention relates to the technical field of chemical pharmacy, in particular to a synthesis method of 3', 5' dichloro-2, 2, 2-trifluoroacetophenone. The method comprises the following steps of: reacting 1, 3, 5-trichlorobenzene or 3, 5-dichloro-1-bromobenzene with magnesium to form a Grignard reagent, carrying out nucleophilic addition reaction on the Grignard reagent and a trifluoroacetyl reagent; and carrying out acid treatment to obtain 3', 5'-dichloro-2, 2, 2-trifluoroacetophenone; the method has the advantages of mild reaction conditions, low raw material cost, favorable economic effect and wide industrial production prospects.

Preparation method of 3,5-dihalo trifluoroacetophenone and derivative thereof

The invention relates to the technical field of chemical pharmacy, particularly to a preparation method of 3,5-dihalo trifluoroacetophenone and a derivative thereof. According to the invention, , thederivatives of 3,5-dihalo trifluoroacetophenone is prepared by using 3-halogen-4-nitro trifluoroacetophenone as a raw material through reduction reaction, halogenation reaction and amino substitutionreaction, wherein the raw materials are cheap and easy to obtain, the process is simple, and the method is mild in condition, has a large-scale production prospect and has a relatively good economic effect.

Preparation method of 3',5'-dichloro-2,2,2-trifluoroacetophenone

The invention relates to the technical field of chemical pharmacy, particularly to a preparation method of 3',5'-dichloro-2,2,2-trifluoroacetophenone. According to the invention, 3',5'-dichloro-2,2,2-trifluoroacetophenone is prepared from 3'-chloro-2,2,2-trifluoroacetophenone as a raw material through four steps of nitrification, reduction, chlorination and deamination, and the method has the advantages of low raw material cost, mild reaction conditions, simple reaction process, facilitation of the reduction of the production cost, and improvement of the economic effect.

ANTIPARASITIC COMPOUNDS

The present invention relates to isothiazoline compounds of formula (I). The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to veterinary compositions comprising said compounds.

Method for preparing 3,5-dichloro-a-(trifluoromethyl)styrene

The invention discloses a method for preparing 3,5-dichloro-a-(trifluoromethyl)styrene (2). The method comprises the following steps: carrying out a substitution reaction on 3,5-dichlorobromobenzene used as an initial raw material and an organic fluorine

PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO

This document discloses molecules having the following formula ("Formula One"): and processes associated therewith.

METHOD FOR PREPARING SUBSTITUTED ISOXAZOLINE COMPOUNDS AND THEIR PRECURSORS 4-CHLORO, 4-BROMO- OR 4-IODOBENZALDEHYDE OXIMES

The present invention relates to a method for preparing 4-chloro-, 4-bromo- or 4- iodobenzaldehyde oximes and phenyl-substituted isoxazoline compounds prepared from these oximes.