1-(2-ethyl-1-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-6-yl)-2,2,2-trifluoroethanone

Base Information

• Chemical Name: 1-(2-ethyl-1-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-6-yl)-2,2,2-trifluoroethanone
• CAS No.: 1236287-41-4
• Molecular Formula: C₁₇H₁₇F₃N₂O
• Molecular Weight: 322.33

Synonyms:1-(2-ethyl-1-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-6-yl)-2,2,2-trifluoroethanone

Chemical Property of 1-(2-ethyl-1-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-6-yl)-2,2,2-trifluoroethanone

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Technology Process of 1-(2-ethyl-1-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-6-yl)-2,2,2-trifluoroethanone

There total 1 articles about 1-(2-ethyl-1-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-6-yl)-2,2,2-trifluoroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

2-Ethyl-1-phenyl-1,2,3,4-tetrahydropyrrolo<1,2-a>pyrazine (73627-30-2) + trifluoroacetic anhydride (407-25-0) → 1-(2-ethyl-1-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-6-yl)-2,2,2-trifluoroethanone (1236287-41-4)

Guidance literature:

2-Ethyl-1-phenyl-1,2,3,4-tetrahydropyrrolo<1,2-a>pyrazine; trifluoroacetic anhydride; With pyridine; In dichloromethane; at 35 ℃;

With sodium carbonate; In dichloromethane; water; pH=9 - 10;

DOI:10.1016/j.tet.2010.04.104

Reference yield: 49.0%

1-(2-ethyl-1-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-6-yl)-2,2,2-trifluoroethanone (1236287-41-4) + propynoic acid methyl ester (922-67-8) → methyl 3-ethyl-6-phenyl-9-(trifluoroacetyl)-1,2,3,6-tetrahydropyrrolo[1,2-a][1,4]diazocine-5-carboxylate

Guidance literature:

In methanol; for 6h; Reflux;

DOI:10.1016/j.tet.2010.04.104

Reference yield: 21.0%

1-(2-ethyl-1-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-6-yl)-2,2,2-trifluoroethanone (1236287-41-4) + methyl ethynyl ketone (1423-60-5) → 1-(5-acetyl-3-methyl-6-phenyl-1,2,3,6-tetrahydropyrrolo[1,2-d][1,4]diazocin-9-yl)-2,2,2-trifluoroethanone (1202747-40-7)

Guidance literature:

In methanol; Reflux;

DOI:10.1016/j.tet.2010.04.104

upstream raw materials:

2-Ethyl-1-phenyl-1,2,3,4-tetrahydropyrrolo<1,2-a>pyrazine

trifluoroacetic anhydride

Downstream raw materials:

1-(5-acetyl-3-methyl-6-phenyl-1,2,3,6-tetrahydropyrrolo[1,2-d][1,4]diazocin-9-yl)-2,2,2-trifluoroethanone

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