4-(2,4-dioxo-8-oxa-1,3-diazaspiro[4.5]decan-3-yl)-2-(trifluoromethyl)-benzonitrile

Base Information

• Chemical Name: 4-(2,4-dioxo-8-oxa-1,3-diazaspiro[4.5]decan-3-yl)-2-(trifluoromethyl)-benzonitrile
• CAS No.: 177337-90-5
• Molecular Formula: C₁₅H₁₂F₃N₃O₃
• Molecular Weight: 339.274

Synonyms:4-(2,4-dioxo-8-oxa-1,3-diazaspiro[4.5]decan-3-yl)-2-(trifluoromethyl)-benzonitrile

Chemical Property of 4-(2,4-dioxo-8-oxa-1,3-diazaspiro[4.5]decan-3-yl)-2-(trifluoromethyl)-benzonitrile

Chemical Property:

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Technology Process of 4-(2,4-dioxo-8-oxa-1,3-diazaspiro[4.5]decan-3-yl)-2-(trifluoromethyl)-benzonitrile

There total 1 articles about 4-(2,4-dioxo-8-oxa-1,3-diazaspiro[4.5]decan-3-yl)-2-(trifluoromethyl)-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-imino-2-oxo-8-oxa-1,3-diazaspiro[4.5]decan-3-yl)-2-(trifluoromethyl)-benzonitrile (177337-89-2) → 4-(2,4-dioxo-8-oxa-1,3-diazaspiro[4.5]decan-3-yl)-2-(trifluoromethyl)-benzonitrile (177337-90-5)

Guidance literature:

With hydrogenchloride; In methanol; chloroform; water; isopropyl alcohol;

Reference yield:

4-(2,4-dioxo-8-oxa-1,3-diazaspiro[4.5]decan-3-yl)-2-(trifluoromethyl)-benzonitrile (177337-90-5) + 4-iodobutoxy-trimethyl-silane (18244-40-1) → 4-(2,4-dioxo 1-(4-hydroxybutyl)-8-oxa-1,3-diazaspiro(4,5) decan-3-yl)-2-(trifluoromethyl) benzonitrile (177337-91-6)

Guidance literature:

With hydrogenchloride; In methanol; chloroform; water; dimethyl sulfoxide;

Reference yield:

4-(2,4-dioxo-8-oxa-1,3-diazaspiro[4.5]decan-3-yl)-2-(trifluoromethyl)-benzonitrile (177337-90-5) + 3-bromopropoxydiphenyl-tert-butyl-silane → 4-(2,4-dioxo-1-(3-hydroxypropyl)-8-oxa-1,3-diazaspiro[4.5]decan-3-yl)-2-(trifluoromethyl)-benzonitrile (177337-93-8)

Guidance literature:

With hydrogenchloride; In methanol; chloroform; dimethyl sulfoxide;

upstream raw materials:

4-(4-imino-2-oxo-8-oxa-1,3-diazaspiro[4.5]decan-3-yl)-2-(trifluoromethyl)-benzonitrile

Downstream raw materials:

4-(2,4-dioxo-1-(2-hydroxyethyl)-8-oxa-1,3-diazaspiro[4.5]decan-3-yl)-2-(trifluoromethyl)-benzonitrile

4-(2,4-dioxo 1-(4-hydroxybutyl)-8-oxa-1,3-diazaspiro(4,5) decan-3-yl)-2-(trifluoromethyl) benzonitrile

4-(2,4-dioxo-1-(3-hydroxypropyl)-8-oxa-1,3-diazaspiro[4.5]decan-3-yl)-2-(trifluoromethyl)-benzonitrile

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