diisopropyl 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonate hydrochloride

Base Information

Chemical Name:diisopropyl 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonate hydrochloride
CAS No.:1606974-15-5
Molecular Formula:C₃₀H₃₃ClN₂O₄*ClH
Molecular Weight:557.517
Hs Code.:

Synonyms:diisopropyl 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonate hydrochloride

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Chemical Property of diisopropyl 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonate hydrochloride

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Technology Process of diisopropyl 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonate hydrochloride

There total 7 articles about diisopropyl 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1606976-67-3
diisopropyl 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonate

: 1606974-15-5
diisopropyl 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonate hydrochloride

Guidance literature:: With hydrogenchloride; In methanol;

Reference yield:

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 1606974-15-5
diisopropyl 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

1.2: 19 h

2.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 2.5 h / 760.05 Torr

3.1: hydrogenchloride / 1-methyl-pyrrolidin-2-one / 2 h / 140 °C / Microwave irradiation

4.1: hydrogenchloride / methanol

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydride; In 1-methyl-pyrrolidin-2-one; methanol; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 13195-64-7
diisopropyl malonate

: 1606974-15-5
diisopropyl 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

1.2: 19 h

2.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 2.5 h / 760.05 Torr

3.1: hydrogenchloride / 1-methyl-pyrrolidin-2-one / 2 h / 140 °C / Microwave irradiation

4.1: hydrogenchloride / methanol

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydride; In 1-methyl-pyrrolidin-2-one; methanol; ethyl acetate; N,N-dimethyl-formamide; mineral oil;