diisopropyl 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonate

Base Information

Chemical Name:diisopropyl 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonate
CAS No.:1606976-67-3
Molecular Formula:C₃₀H₃₃ClN₂O₄
Molecular Weight:521.056
Hs Code.:

Synonyms:diisopropyl 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonate

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Chemical Property of diisopropyl 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonate

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Technology Process of diisopropyl 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonate

There total 6 articles about diisopropyl 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1606976-66-2
diisopropyl 2-(4-aminobenzyl)malonate

: 1606976-40-2
4-chloro-2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridine hydrochloride

: 1606976-67-3
diisopropyl 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonate

Guidance literature:: With hydrogenchloride; In 1-methyl-pyrrolidin-2-one; at 140 ℃; for 2h; Microwave irradiation;

Reference yield:

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 1606976-67-3
diisopropyl 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

1.2: 19 h

2.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 2.5 h / 760.05 Torr

3.1: hydrogenchloride / 1-methyl-pyrrolidin-2-one / 2 h / 140 °C / Microwave irradiation

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydride; In 1-methyl-pyrrolidin-2-one; methanol; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 13195-64-7
diisopropyl malonate

: 1606976-67-3
diisopropyl 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

1.2: 19 h

2.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 2.5 h / 760.05 Torr

3.1: hydrogenchloride / 1-methyl-pyrrolidin-2-one / 2 h / 140 °C / Microwave irradiation

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydride; In 1-methyl-pyrrolidin-2-one; methanol; ethyl acetate; N,N-dimethyl-formamide; mineral oil;